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©The Author(s) 2025.
World J Nephrol. Dec 25, 2025; 14(4): 109767
Published online Dec 25, 2025. doi: 10.5527/wjn.v14.i4.109767
Table 5 Three generations of hepatitis B vaccines
Vaccine generation
Hepatitis B antigen
Examples
Remarks
FirstSHBs protein Heptavax-B (Merck & Co., United States); Hevac B (Pasteur, France); KGC (Korea Green Cross, Korea)Not in use
SecondSHBs, MHBs protein Recombivax (Merck & Co., United States); Engerix-B (GSK, Belgium); TGP 943 [P31] (Takeda, Japan); Fendrix (GSK, Belgium); HBVaxPro (Sanofi-Pasteur, MSD)Most commonly used and easily available
ThirdSHBs, MHBs, Large hepatitis B surface proteinGenHevac B (Pasteur, France); Bio-Hep-B (Bio Technology General, Israel)Limited availability and higher costs


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