©The Author(s) 2025.
World J Nephrol. Dec 25, 2025; 14(4): 109457
Published online Dec 25, 2025. doi: 10.5527/wjn.v14.i4.109457
Published online Dec 25, 2025. doi: 10.5527/wjn.v14.i4.109457
Figure 2 Potential kidney-cardiovascular and metabolic effects of semaglutide in people with chronic kidney disease.
ANP: Atrial natriuretic peptide; BP: Blood pressure; CKD: Chronic kidney disease; CV: Cardiovascular; HbA1c: Glycated haemoglobin; KIM-1: Kidney injury molecule-1; LDL-C: Low-density lipoprotein cholesterol; NF-κB: Nuclear factor-κB; NHE3: Sodium-hydrogen exchanger-3; NO: Nitric oxide; RAAS: Renin-angiotensin-aldosterone system; RAGE: Receptor for advanced glycation end products; TGF-β: Transforming growth factor-β. Created in BioRender (https://BioRender.com/yd9812v).
- Citation: Economos H, MacIsaac RJ. Cardio-kidney-metabolic protective effects of semaglutide across the spectrum of chronic kidney disease. World J Nephrol 2025; 14(4): 109457
- URL: https://www.wjgnet.com/2220-6124/full/v14/i4/109457.htm
- DOI: https://dx.doi.org/10.5527/wjn.v14.i4.109457