Cardamom extract: An effective weapon in prevention of cardiorenal syndrome induced in rats by cisplatin and high-fat diet

Table 5 ∆G Binding affinity (kcal/mol) for each ligand with Hippo signaling pathway proteins

Name of the ligand	MST1	LATS1	YAP	TAZ
	Binding free energy (kcal/mol)
Caffeic acid	-6.9	-6.1	-5.5	-4.8
Chlorogenic	-7.6	-7.7	-6.8	-5.8
Cinnamic acid	-6.3	-6	-5.7	-4.6
Coumaric acid	-6.5	-6.1	-5.8	-4.8
Ellagic acid	-8.7	-7.7	-6	-6.3
Ferulic acid	-7	-6.3	-5.5	-4.6
Gallic acid	-5.8	-6.2	-5	-4.5
Hesperetin	-8	-7.3	-6.6	-6.3
Methyl gallate	-5.8	-5.4	-4.9	-4.4
Naringenin	-7.8	-8.1	-6.5	-6.1
Quercetin	-7.4	-8.3	-6.5	-6
Rosmarinic	-7.9	-7.2	-6.5	-6.1
Rutin	-8.3	-8.9	-7.5	-7.4
Syringic acid	-5.9	-5.4	-5	-4.2
Vanillin	-5.7	-5.2	-4.6	-3.9

MST1: Mammalian sterile 20-like kinase 1, LATS1: Large tumor suppressor kinase 1, YAP: Yes-associated protein, TAZ: Transcriptional coactivator with PDZ-binding motif.