Cardamom extract: An effective weapon in prevention of cardiorenal syndrome induced in rats by cisplatin and high-fat diet

Table 3 Effect of cardamom extract on renal biochemical parameter in plasma and urine of rats

	Normal control	Cardiorenal control	Low-dose cardamom extract	High-dose cardamom extract
	Plasma
Creatinine (mg/dL)	0.59a ± 0.012	1.44b ± 0.049	0.98b,d ± 0.028	0.77a,d,f ± 0.024
Urea (mg/dL)	32.92a ± 0.709	159.22b ± 3.017	89.79b,d ± 2.365	64.51b,d,f ± 1.252
Albumin (g/dL)	3.91a ± 0.076	2.53b ± 0.046	3.03b,d ± 0.057	3.70d,f ± 0.090
BUN (mg/dL)	15.38a ± 0.331	74.36b ± 1.409	41.93c ± 1.104	30.13d ± 0.585
BUN/creatinine ratio	26.17a ± 0.932	52.13b ± 1.861	43.00b,d ± 1.759	39.15b,d,f ± 1.252
Total protein (g/dL)	7.73a ± 0.062	5.31b ± 0.075	6.30b,d ± 0.098	7.19a,d,f ± 0.114
	Urine
Creatinine (mg/dL)	37.78a ± 0.582	52.71b ± 1.038	46.14b,c ± 1.578	40.71d,e ± 0.746
Urea (mg/dL)	657.77a ± 5.282	984.63b ± 8.335	823.57b,d ± 9.541	697.86a,d,f ± 8.840
Protein (mg/dL)	41.94a ± 0.921	67.29b ± 1.246	62.57b,d ± 1.268	50.00b,d,f ± 0.898
Creatinine clerance (ml/min)	1.24a ± 0.041	0.48b ± 0.033	0.75b,d ± 0.049	0.97b,d,f ± 0.035

^aP < 0.01.

^bP < 0.001, statistical significance is expressed vs normal control.

^cP < 0.01.

^dP < 0.001, P values are expressed vs cardiorenal-control.

^eP < 0.01.

^fP < 0.001, P values are expressed (Low-dose cardamom extract vs high-dose cardamom extract). Values are mean ± SE, n = 6.