Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients

Table 3 Liver fibrosis indexes according to the single nucleotide polymorphisms genotypes

SNP	Genotype	Transient elastometry	YFPI1	APRI	Forns	FIB-4
MMP-1 -1607 1G/2G	1G1G	5.583 (4.600-6.567)	0.346 (0.215-0.477)	0.693 (0.192-1.195)	3.719 (2.860-4.579)	1.317 (0.723-1.911)
	1G2G	5.911 (4.649-7.174)	0.470 (0.250-0.691)	0.488 (0.307-0.670)	4.253 (3.430-5.077)	1.092 (0.859-1.324)
	2G2G	8.781 (5.585-11.977)	0.689 (0.378-1.001)	0.675 (0.453-0.897)	4.390 (3.914-4.867)	1.479 (1.097-1.862)
	P value	0.3	0.3	0.7	0.4	0.5
MMP-8 -799C/T	CC	6.644 (3.736-9.553)	0.633 (0.074-1.193)	0.615 (0.411-0.819)	4.510 (3.920-5.099)	1.461 (1.058-1.864)
	CT	5.628 (5.060-6.196)	0.357 (0.275-0.439)	0.453 (0.347-0.559)	4.126 (3.701-4.551)	1.145 (1.014-1.277)
	TT	7.729 (4.540-10.918)	0.671 (0.376-0.965)	0.768 (0.447-1.088)	4.407 (3.825-4.989)	1.603 (1.081-2.125)
	P value	0.4	0.19	0.1	0.5	0.15
MMP-9 -1562 C/T	CC	7.540 (5.810-9.269)	0.527 (0.361-0.694)	0.612 (0.475-0.749)	4.370 (4.024-4.717)	1.404 (1.163-1.645)
	CT	11.178 (4.093-18.264)	0.833 (0.229-1.437)	0.867 (0.412-1.323)	5.083 (4.024-6.142)	2.043 (1.044-3.041)
	TT	-	-	-	-	-
	P value	0.14	0.16	0.16	0.11	0.065
MMP-13 -77A/G	AA	7.217 (5.654-8.780)	0.535 (0.358-0.712)	0.623 (0.480-0.766)	4.352 (3.993-4.711)	1.462 (1.185-1.738)
	AG	8.721 (4.646-12.798)	0.700 (0.291-1.109)	0.698 (0.426-0.970)	4.588 (3.998-5.177)	1.553 (1.109-1.998)
	GG	-	-	-	-	-
	P value	0.4	0.4	0.6	0.5	0.7
TNF-α -308 G/A	AA	10.073 (1.300-18.849)	0.656 (0.132-1.180)	0.693 (0.135-1.250)	4.331 (3.280-5.383)	1.584 (0.693-2.475)
	AG	8.086 (5.779-10.394)	0.552 (0.336-0.767)	0.675 (0.495-0.855)	4.603 (4.174-5.033)	1.575 (1.210-1.940)
	GG	7.514 (4.623-10.404)	0.620 (0.228-1.012)	0.701 (0.405-0.997)	4.221 (3.513-4.929)	1.466 (1.021-1.910)
	P value	0.7	0.9	0.99	0.6	0.9
CCR5-Δ32	wt/wt	7.852 (5.998-9.707)	0.590 (0.399-0.783)	0.664 (0.525-0.803)	4.439 (4.102-4.775)	1.513 (1.264-1.762)
	wt/Δ32	6.521 (4.109-8.934)	0.545 (0.232-0.858)	0.539 (0.230-0.847)	4.391 (3.684-5.098)	1.335 (0.699-1.971)
	Δ32/Δ32	-	-	-	-	-
	P value	0.5	0.9	0.4	0.9	0.6

¹YFPI: Yearly fibrosis progression index (only for HCV-infected patients); SNP: Single nucleotide polymorphisms; MMP: Matrix metalloprotease. Values are expressed as mean (95%CI) in ng/mL; APRI: AST to Platelet Ratio Index; FIB-4: Fibrosis-4 index.