Regulation of Wnt/β-catenin signaling by herpesviruses

Figure 4 Kaposi’s sarcoma-associated herpesvirus latency upregulates β-catenin. Establishment of KSHV latency involves expression of the latency associated protein LANA. LANA binds with and translocates GSK-3 into the nucleus after phosphorylation by GSK-3. This translocation of cytoplasmic pools of GSK-3 prevents β-catenin destruction complex formation and stability of cytoplasmic β-catenin. β-catenin translocation to the nucleus occurs resulting in increased β-catenin-mediated transcription. LANA: Latency-associated nuclear antigen; KSHV: Kaposi’s sarcoma-associated herpesvirus.