Inflammatory and oxidative stress in rotavirus infection

Table 1 Cell surface molecules interacting with rotavirus structural proteins during entry

Cellular molecule	Rotavirus protein	Activity	Viral protein motif involved	Ref.
Sialic acid	VP8*	Binding	Carbohydrate binding site	[108]
α2β1	VP5*	Post-binding	DGE (VP5*)	[106]
α4β1	VP7, VP5*	Post-binding	YGL (VP5*); LDV o LDI (VP7)	[11,121]
αxβ2	VP7	Post-binding	GPR (VP7)	[114,121]
αvβ3	VP7	Post-binding, oxidoreduction	161NEWLCNPMD169	[10,113]
Hsc70	VP5*, VP7, VP6	Chaperoning	aa 642-658 (VP5*); aa 280-296 (VP6); aa 531-554 (VP5*)	[8,103]
PDI	VP5*, VP7, VP6	Chaperoning, oxidoreduction	aa 200-219 (VP4); aa 189-210 and aa 243-263 (VP7)	[12,94, Rivera M, Guerrero CA, Acosta O, manuscript in preparation]
HBGAs	VP8*	Binding	Carbohydrate binding site	[111]

Hsc70: Heat shock cognate protein 70; PDI: Protein disulfide isomerase; HBGAs: Histo-blood group antigens.