Herpes zoster vaccination in inflammatory bowel disease: Evidence, guidelines, and reality

doi:10.5501/wjv.121081

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World Journal of Virology

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2220-3249

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Virol. Sep 25, 2026; 15(3): 121081
Published online Sep 25, 2026. doi: 10.5501/wjv.121081

Table 1 Epidemiology of herpes zoster in inflammatory bowel disease and general population - herpes zoster in inflammatory bowel disease vs healthy population[3,5,6,10,11,12,14]

Parameter	General	IBD
Incidence/1000 PY	3.4 to 4.82	7.0 to 18.3
Relative risk		1.3-fold to 2.0-fold higher
Lifetime risk	25% to 30%	High-risk thresholds reached much earlier
Age-specific risk	Risk rises with age	Higher relative risk than age-matched healthy controls
Gender distribution	1.3 times higher incidence in females	Higher incidence in females

PY: Patient-years; IBD: Inflammatory bowel disease.

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Citation: Manrai M, Pachisia AV, Jha AA, Shukla R, Hande V, Thareja S. Herpes zoster vaccination in inflammatory bowel disease: Evidence, guidelines, and reality. World J Virol 2026; 15(3): 121081
URL: https://www.wjgnet.com/2220-3249/full/v15/i3/121081.htm
DOI: https://dx.doi.org/10.5501/wjv.121081

Manrai M, Pachisia AV, Jha AA, Shukla R, Hande V, Thareja S. Herpes zoster vaccination in inflammatory bowel disease: Evidence, guidelines, and reality. World J Virol 2026; 15(3): 121081 [PMID: 42781251 DOI: 10.5501/wjv.121081]

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