Discontinuation of nucleos(t)ide analog therapy in hepatitis B e antigen-negative non-cirrhotic chronic hepatitis B patients: A real-life study

doi:10.5501/wjv.120124

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World Journal of Virology

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2220-3249

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World J Virol. Sep 25, 2026; 15(3): 120124
Published online Sep 25, 2026. doi: 10.5501/wjv.120124

Table 2 Cumulative rates of virological, biochemical or combined relapse in 87 non-cirrhotic patients with hepatitis B e antigen-negative chronic hepatitis B who discontinued nucleos(t)ide analog therapy, n(%)

Discontinuation of NUCs (n = 87)	HBV DNA > 200 IU/mL	HBV DNA > 2000 IU/mL			HBV DNA > 20000 IU/mL
Discontinuation of NUCs (n = 87)	ALT = ULN	ALT = ULN	ALT > ULN	ALT > 2ULN	ALT = ULN	ALT > ULN
6 months	36	25	2	2	8	2
12 months	63	52	28	23	21	18
24 months	65	58	32	27	28	22
36 months	68	61	34	27	28	22

NUCs: Nucleos(t)ide analogues; HBV: Hepatitis B viral; DNA: Deoxyribonucleic acid; ALT: Alanine aminotransferase; ULN: Upper limit of normal.

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Citation: Amalou K, Rekab R, Benmellouka N, Derbal B, Belloula A, Chetroub H, Sabrina F, Belghanem F, Saidani K. Discontinuation of nucleos(t)ide analog therapy in hepatitis B e antigen-negative non-cirrhotic chronic hepatitis B patients: A real-life study. World J Virol 2026; 15(3): 120124
URL: https://www.wjgnet.com/2220-3249/full/v15/i3/120124.htm
DOI: https://dx.doi.org/10.5501/wjv.120124

Amalou K, Rekab R, Benmellouka N, Derbal B, Belloula A, Chetroub H, Sabrina F, Belghanem F, Saidani K. Discontinuation of nucleos(t)ide analog therapy in hepatitis B e antigen-negative non-cirrhotic chronic hepatitis B patients: A real-life study. World J Virol 2026; 15(3): 120124 [PMID: 42780577 DOI: 10.5501/wjv.120124]

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