Unveiling the viral dimension: The paediatric gut virome as a key modulator of gastrointestinal metabolic, and neurodevelopmental health

doi:10.5501/wjv.v15.i1.118362

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World Journal of Virology

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2220-3249

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Virol. Mar 25, 2026; 15(1): 118362
Published online Mar 25, 2026. doi: 10.5501/wjv.v15.i1.118362

Table 7 Summary of clinical frontiers

Modality	Strategy	Primary advantage
Biomarkers	Viral “Fingerprinting”	Early detection before symptoms or bacterial shifts. AI-driven “Early Warning Systems” for high-risk neonates
Phage therapy	Targeting pathobionts	Highly specific; preserves the “good” microbiome. Routine “precision editing” for pathobiont-driven IBD
FVT	Sterile filtrate transfer	Safer than whole-fecal transplants for children. FVT is a primary “reset” for metabolic and immune health
Nutrition	Indirect modulation	Scalable and low risk for long-term health

FVT: Fecal viral transplantation; IBD: Inflammatory bowel disease.

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Citation: Saeed NK, Elbeltagi YM, Al-Beltagi M. Unveiling the viral dimension: The paediatric gut virome as a key modulator of gastrointestinal metabolic, and neurodevelopmental health. World J Virol 2026; 15(1): 118362
URL: https://www.wjgnet.com/2220-3249/full/v15/i1/118362.htm
DOI: https://dx.doi.org/10.5501/wjv.v15.i1.118362

Saeed NK, Elbeltagi YM, Al-Beltagi M. Unveiling the viral dimension: The paediatric gut virome as a key modulator of gastrointestinal metabolic, and neurodevelopmental health. World J Virol 2026; 15(1): 118362 [PMID: 41884457 DOI: 10.5501/wjv.v15.i1.118362]

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