©The Author(s) 2025.
World J Virol. Dec 25, 2025; 14(4): 110435
Published online Dec 25, 2025. doi: 10.5501/wjv.v14.i4.110435
Published online Dec 25, 2025. doi: 10.5501/wjv.v14.i4.110435
Table 9 Frequencies of amino acid mutations in adeno-associated virus-2 genomes from cases of acute hepatitis of unknow etiology
| Proteins | Amino acid mutation | England | Scotland | United States | Controls | |
| Including recent published data | Published data before 2016 | |||||
| Rep 78, 52 | T183A | 100 (15/15) | 100 (9/9) | 100 (12/12) | 97 (29/30) | 93 (28/30) |
| K474Q | 33 (5/15) | 66 (6/9) | 67 (4/6) | 20 (6/30) | 13 (4/30) | |
| V508A | 100 (15/15) | 100 (9/9) | 100 (4/4) | 97 (29/30) | 93 (28/30) | |
| T605S | 27 (4/15) | 0 (0/9) | 60 (3/5) | 17 (5/30) | 17 (5/30) | |
| L609V/M | 73 (11/15) | 89 (8/9) | 25 (1/5) | 33 (10/30) | 20 (6/30) | |
| F619S | 100 (15/15) | 100 (9/9) | 67 (2/3) | 97 (29/30) | 97 (29/30) | |
| AAP | Q6P | 100 (15/15) | 100 (9/9) | 60 (3/5) | 93 (28/30) | 93 (28/30) |
| E70A | 93 (14/15) | 89 (8/9) | 100 (13/13) | 57 (17/30) | 30 (9/30) | |
| P73 L | 93 (14/15) | 89 (8/9) | 100 (13/13) | 73 (22/30) | 50 (15/30) | |
| T80I | 87 (13/15) | 100 (9/9) | 100 (11/11) | 67 (20/30) | 47 (14/30) | |
| S81C | 87 (13/15) | 100 (9/9) | 100 (11/11) | 67 (20/30) | 43 (13/30) | |
| N83S | 73 (11/15) | 89 (8/9) | 100 (11/11) | 80 (24/30) | 93 (28/30) | |
| K84R | 93 (14/15) | 67 (6/9) | 100 (11/11) | 73 (22/30) | 57 (17/30) | |
| N88S | 27 (4/15) | 0 (0/9) | 56 (5/9) | 20 (6/30) | 33 (10/30) | |
| Q89 L | 27 (4/15) | 0 (0/9) | 56 (5/9) | 20 (6/30) | 33 (10/30) | |
| R92A | 53 (8/15) | 0 (0/9) | 83 (5/6) | 40 (12/30) | 37 (11/30) | |
| I95T | 100 (15/15) | 100 (9/9) | 86 (6/7) | 93 (28/30) | 97 (29/30) | |
| L103P | 87 (13/15) | 56 (5/9) | 100 (6/6) | 57 (17/30) | 73 (22/30) | |
| F116S | 20 (3/15) | 67 (6/9) | 50 (2/4) | 23 (7/30) | 23 (7/30) | |
| H117P | 13 (2/15) | 67 (6/9) | 67 (2/3) | 23 (7/30) | 20 (6/30) | |
| D132G | 73 (11/15) | 67 (6/9) | 57 (4/7) | 60 (18/30) | 53 (16/30) | |
| T137A | 20 (3/15) | 11 (1/9) | 67 (4/6) | 10 (3/30) | 17 (5/30) | |
| K146R | 47 (7/15) | 22 (2/9) | 100 (6/6) | 47 (14/30) | 43 (13/30) | |
| VP1-3 | R81Q | 0 (0/15) | 0 (0/9) | 50 (6/12) | 0 (0/30) | 0 (0/30) |
| V125I | 0 (0/15) | 0 (0/9) | 60 (6/10) | 3 (1/30) | 10 (3/30) | |
| V151A | 87 (13/15) | 89 (8/9) | 82 (9/11) | 60 (18/30) | 0 (0/30) | |
| A162S | 33 (5/15) | 44 (4/9) | 56 (5/9) | 23 (7/30) | 10 (3/30) | |
| Q164N | 47 (7/15) | 67 (6/9) | 11 (1/9) | 37 (11/30) | 27 (8/30) | |
| T205S | 60 (9/15) | 22 (2/9) | 25 (1/4) | 23 (7/30) | 43 (13/30) | |
| N312S | 20 (3/15) | 11 (1/9) | 60 (3/5) | 10 (3/30) | 17 (5/30) | |
| R447K | 20 (3/15) | 56 (5/9) | 18 (2/11) | 30 (9/30) | 33 (10/30) | |
| T450A | 14 (2/14) | 56 (5/9) | 10 (1/10) | 10 (3/30) | 0 (0/30) | |
| Q457M1 | 93 (13/14) | 100 (9/9) | 86 (6/7) | 40 (12/30) | 23 (7/30) | |
| S492A | 100 (14/14) | 100 (9/9) | 50 (1/2) | 87 (26/30) | 80 (24/30) | |
| S492D | 0 (0/14) | 0 (0/9) | 50 (1/2) | 0 (0/30) | 0 (0/30) | |
| E499D1 | 93 (13/14) | 100 (9/9) | 100 (3/3) | 47 (14/30) | 23 (7/30) | |
| P521T | 67 (10/15) | 89 (8/9) | 33 (1/3) | 20 (6/30) | 0 (0/30) | |
| F533Y1 | 87 (13/15) | 100 (9/9) | 50 (1/2) | 43 (13/30) | 20 (6/30) | |
| E548G | 20 (3/15) | 44 (4/9) | 50 (1/2) | 37 (11/30) | 33 (10/30) | |
| D553E | 7 (1/15) | 0 (0/9) | 50 (1/2) | 0 (0/30) | 7 (2/30) | |
| R585S | 93 (14/15) | 100 (9/9) | 100 (10/10) | 73 (22/30) | 50 (15/30) | |
| R588T | 100 (15/15) | 100 (9/9) | 100 (10/10) | 97 (29/30) | 93 (28/30) | |
| A593S | 47 (7/15) | 44 (4/9) | 70 (7/10) | 53 (16/30) | 37 (11/30) | |
- Citation: Komatsu H. Comparison of three pediatric studies investigating acute hepatitis of unknown etiology. World J Virol 2025; 14(4): 110435
- URL: https://www.wjgnet.com/2220-3249/full/v14/i4/110435.htm
- DOI: https://dx.doi.org/10.5501/wjv.v14.i4.110435