Comparison of three pediatric studies investigating acute hepatitis of unknown etiology

doi:10.5501/wjv.v14.i4.110435

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World Journal of Virology

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2220-3249

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Virol. Dec 25, 2025; 14(4): 110435
Published online Dec 25, 2025. doi: 10.5501/wjv.v14.i4.110435

Table 7 Rate of positivity for human adenovirus and/or human herpes viruses in adeno-associated virus-2-infected cases of acute hepatitis of unknown etiology according to metagenomic sequencing

Detected viruses	England	Scotland	United States
	n = 9	n = 9	Case, n = 13	Control, n = 4
AAV-2 + HAdV	11% (1/9)	33% (3/9)	46% (6/13)	75% (3/4)
AAV-2 + HAdV + HHV-6B + VZV		11% (1/9)
AAV-2 + HAdV + HHV-7 + CMV		11% (1/9)
AAV-2 + HAdV + HHV-6B + CMV		11% (1/9)
AAV-2 + HAdV + EBV			15% (2/13)
AAV-2 + HAdV + CMV			8% (1/13)
AAV-2 + HAdV + EV-71			8% (1/13)
AAV-2 + HHV-6B	56% (5/9)
AAV-2 + EBV	11% (1/9)
AAV-2 + HHV-6B + EBV		11% (1/9)
Total	78% (7/9)	78% (7/9)	77% (10/13)	75% (3/4)

AAV: Adeno-associated virus; CMV: Cytomegalovirus; EBV: Epstein-Barr virus; EV: Enterovirus; HAdV: Human adenovirus; HHV: Human herpes virus; VZV: Varicella-zoster virus.

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Citation: Komatsu H. Comparison of three pediatric studies investigating acute hepatitis of unknown etiology. World J Virol 2025; 14(4): 110435
URL: https://www.wjgnet.com/2220-3249/full/v14/i4/110435.htm
DOI: https://dx.doi.org/10.5501/wjv.v14.i4.110435

Komatsu H. Comparison of three pediatric studies investigating acute hepatitis of unknown etiology. World J Virol 2025; 14(4): 110435 [PMID: 41479581 DOI: 10.5501/wjv.v14.i4.110435]

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