Comparison of three pediatric studies investigating acute hepatitis of unknown etiology

Table 6 Rates of positivity for adeno-associated virus, human adenovirus and human herpes viruses in cases of acute hepatitis of unknown etiology according to metagenomic sequencing and real-time polymerase chain reaction

Viruses	England		Scotland		United States
	Metagenomic sequencing	PCR	Metagenomic sequencing	PCR	Metagenomic sequencing	PCR
AAV-2	90% (9/10)	96.4% (27/28)	100% (9/9)	81.2% (26/32)	81.3% (13/16)	ND
HAdV	10% (1/10)	75% (24/32)	66.7% (6/9)	18.5% (5/27)	75% (12/16)	100% (16/16)
HHV-6	50% (5/10)	69.6% (16/23)	75% (3/4)	11.1% (3/27)	0% (0/16)	43.8% (7/16)
VZV	0% (0/10)	ND	25% (1/4)	ND	0% (0/16)	ND
EBV	10% (1/10)	ND	25% (1/4)	ND	12.5% (2/16)	68.8% (11/16)
CMV	30% (3/10)	ND	50% (2/4)	ND	6.3% (1/16)	0% (0/16)
HHV-7	20% (2/10)	ND	25% (1/4)	ND	0% (0/16)	ND

AAV: Adeno-associated virus; CMV: Cytomegalovirus; EBV: Epstein-Barr virus; EV: Enterovirus; HAdV: Human adenovirus; HHV: Human herpes virus; VZV: Varicella-zoster virus; ND: No data.