Comparison of three pediatric studies investigating acute hepatitis of unknown etiology

Table 3 Methods of investigation for acute hepatitis of unknown etiology in children

	England	Scotland	United States
1 Metagenomic sequencing	○	○	○
2 Viral whole-genome sequencing	○	○	○
3 Virus-specific real-time PCR	○	○	○
4 Liver histology	○	○	○
5 Nanopore sequencing	○
6 Transduction of AAV-2 capsid mutation	○
7 Cytokine transcriptomics analysis	○
8 Proteomic analysis	○
9 Longitudinal analysis (AAV-2 PCR and AAV2 IgG/IgM)		○
10 Severe acute respiratory syndrome coronavirus 2 infection		○
11 HLA typing	○	○

AAV: Adeno-associated virus; HLA: Human leukocyte antigen; PCR: Polymerase chain reaction.