Comparison of three pediatric studies investigating acute hepatitis of unknown etiology

Table 11 Frequencies of human leukocyte antigen

	Scotland			England
	Case	Control		Case
Positive for at least one copy of the HLA-DRB1*04:01	92.6% (25/27)	15.6% (10/64)		92.3% (12/13)
Allele frequency of the HLA-DRB1*04:01	0.54	0.08	Odds ratio 13.7 (95%CI: 5.5-35.1), P = 5.49 × 10-12	0.54
Positive for at least one copy of the HLA-DQA1*03:03	85.2% (23/27)	17.2% (11/64)		84.6% (11/13)
Allele frequency of the HLA-DQA1*03:03	0.54	0.09	Odds ratio 12.3 (95%CI: 5.1-30.7), P = 1.9 × 10-11	0.5
Positive for at least one copy of the HLA-DRB4*01:03	96.3% (26/27)	32.8% (21/64)		No data
Allele frequency of the HLA-DRB4*01:03	0.67	0.17	Odds ratio 9.4 (95%CI: 4.4-21.3), P = 1.8 × 10-10

HLA: Human leukocyte antigen.