Lassa fever: A comprehensive review of virology, clinical management, and global health implications

Table 3 Treatment and management strategies for Lassa fever

Component	Objective	Key interventions
Antiviral therapy	Inhibit viral replication	Intravenous ribavirin (ideally within first 6 days); oral ribavirin for mild or remote settings
Supportive care	Stabilize and support vital functions	Intravenous fluids and electrolyte balance; nutritional support; oxygen therapy; antipyretics; blood transfusions
Severe case management	Manage complications and prevent multiorgan failure	Antibiotics for secondary infections; dialysis for renal failure; ventilation support; seizure control
Pregnancy-specific care	Reduce maternal and fetal mortality	Specialized obstetric care; consider therapeutic abortion in advanced pregnancy with severe infection
Post-recovery care	Promote long-term recovery and quality of life	Audiology screening and support; psychological counseling; physical rehabilitation and follow-up