Chronic hepatitis B: Is it time for expanded antiviral treatment?

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World Journal of Virology

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2220-3249

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Virol. Sep 25, 2025; 14(3): 103347
Published online Sep 25, 2025. doi: 10.5501/wjv.v14.i3.103347

Table 9 Cost-effectiveness of expanded hepatitis B virus treatment in high and low-income countries

Ref.	Country	Expanded HBV treatment criteria	ICER/DALY averted	Cost-effectiveness threshold¹
Razavi-Shearer et al[71], 2023	United States	Treat all	$41700	$65850
Sanai et al[72], 2020	Saudi Arabia	Treat all	$22500	$66150
Lim et al[73], 2022	Korea	Simplified algorithm (only HBV DNA)	$2583²	$22000
Crossan et al[74], 2016	United Kingdom	Treat all	£28137	£20000
Nguyen et al[75], 2024	The Gambia	Treat all	$2149	$352

¹Cost effectiveness threshold: 0.5 × per capita GDP.

²Simplified algorithm (only DNA, no alanine aminotransferase, hepatitis B e antigen).

ICER: Incremental cost-effectiveness ratio; DALY: Disability-adjusted life year; HBV: Hepatitis B virus.

Citation: Manrai M, Jha AA, Pachisia AV, Dawra S. Chronic hepatitis B: Is it time for expanded antiviral treatment? World J Virol 2025; 14(3): 103347
URL: https://www.wjgnet.com/2220-3249/full/v14/i3/103347.htm
DOI: https://dx.doi.org/10.5501/wjv.v14.i3.103347

Manrai M, Jha AA, Pachisia AV, Dawra S. Chronic hepatitis B: Is it time for expanded antiviral treatment? World J Virol 2025; 14(3): 103347 [PMID: 41025085 DOI: 10.5501/wjv.v14.i3.103347]

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