Evaluation of hyaluronic acid and type III procollagen peptide as predictors for treatment response to direct-acting antivirals

Figure 2 Index development and treatment failure prediction. A: Multiplication of hyaluronic acid (HA) by type III procollagen N-peptide (PIIINP) values is the beast model for significant prediction of treatment failure; B: The best cut-off points of HA × PIIINP model is 1840 μg/mL; C: At this value, HA × PIIINP model has good and significant ability for early distinguishing non-responders from patients with sustained virological response 24. HA: Hyaluronic acid; PIIINP: Type III procollagen N-peptide; SVR: Sustained virological response; AUC: Area under the receiver operating characteristic curve.