Evaluation of hyaluronic acid and type III procollagen peptide as predictors for treatment response to direct-acting antivirals

Table 3 Correlation between the index and each marker alone with factors related to treatment failure

Variable	HA × PIIINP		HA		PIIINP
	r	P value	r	P value	r	P value
ALT (U/L)	0.182	0.091	0.127	0.096	0.121	0.210
AST (U/L)	0.212	0.089a	0.114	0.133	0.150	0.182
ALP (U/L)	0.191	0.059	0.112	0.214	0.071	0.261
Albumin (g/dL)	-0.26	0.021a	-0.20	0.044a	-0.201	0.043a
Bilirubin (mg/dL)	0.194	0.062	0.136	0.079	0.099	0.223
Platelets (× 109/L)	-0.19	0.058	-0.13	0.083	-0.123	0.158
FIB-4	0.216	0.022a	0.186	0.041a	0.185	0.041a
APRI	0.223	0.019a	0.188	0.041a	0.181	0.041a

^aP < 0.05 was significant.

Pearson correlation coefficients were measured for linear relationships. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; FIB-4: Fibrosis-4 score; APRI: Aspartate aminotransferase-platelet ratio index; PIIINP: Type III procollagen N-peptide; HA: Hyaluronic acid.