Evaluation of hyaluronic acid and type III procollagen peptide as predictors for treatment response to direct-acting antivirals

Table 2 Diagnostic performances of the index compared to each marker alone

Categories	AUC (95%CI)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Accuracy (%)
PIIINP ≥ 19.5 μg/L	0.684 (0.59-0.78)	69.3	50	51.0	68.5	58.3
HA ≥ 82 μg/L	0.766 (0.66-0.87)	70.7	69	63.1	75.8	69.71
PIIINP × HA > 1840	0.809 (0.72-0.90)	74.7	74	68.3	79.6	74.3

Cut-off values were obtained from receiver operating characteristic curve analysis. Non-responder patients were compared to responder patients. PIIINP: Type III procollagen N-peptide; HA: Hyaluronic acid; AUC: Area under the receiver operating characteristic curve; PPV: Positive predictive value; NPV: Negative predictive value; CI: Confidence interval.