Evaluation of hyaluronic acid and type III procollagen peptide as predictors for treatment response to direct-acting antivirals

Table 1 Patients’ characteristics, mean ± SD

Variables	Non-responder	Responder	P value
Gender (male/female)	30/45	40/60	0.242
Age (years)	51.55 ± 6.99	49.4 ± 7.0	0.071
Alanine aminotransaminase (U/L)	70.2 ± 21.0	60.0± 15.8	0.017
Aspartate aminotransaminase (U/L)	68.9 ± 16.9	54.6 ± 14.9	0.004
ALP (U/L)	123.9 ± 32.8	98.9 ± 20.9	0.018
Bilirubin (mg/dL)	1.15 ± 0.28	0.96 ± 0.35	0.011
Albumin (g/dL)	3.35 ± 0.39	3.88 ± 0.51	0.0001
Creatinine (mg/dL)	0.87 ± 0.18	0.81 ± 0.16	0.082
α-fetoprotein (ng/mL)	3.62 ± 1.19	3.59 ± 0.88	0.769
INR	1.25 ± 0.15	1.13 ± 0.06	0.069
Hemoglobin (g/dL)	11.88 ± 2.60	13.10 ± 1.34	0.071
Platelets (× 109/L)	155.9 ± 43.9	191.2 ± 35.9	0.0001
White blood cells (× 109/L)	4.91 ± 1.67	5.49 ± 1.37	0.0620
Red blood cells (× 1012/L)	5.33 ± 1.88	4.98 ± 1.17	0.0840
APRI	1.20 ± 0.31	0.78 ± 0.22	0.0001
FIB-4	3.11 ± 1.01	1.94 ± 0.56	0.0001

P < 0.05 was significant.

ALP: Alkaline phosphatase; INR: international normalized ratio; APRI: Aspartate aminotransferase-platelet ratio index; FIB-4: Fibrosis-4 score.