Marburg virus disease: Emerging threat, pathogenesis, and global public health strategies

Table 5 Treatment and next steps

Vaccine/treatment	Type	Trial phase	Key findings	Next steps
cAd3-Marburg	Chimpanzee adenovirus vector	Phase 1	95% immune response in participants	Phase 2 trials pending
Mvabea (MVA-BN-Filo)	Modified Vaccinia Ankara	Phase 1	Safe, good immune response	Phase 2/3 trials planned
Marburg virus DNA plasmid vaccine	DNA-based vaccine	Phase 1	Early immune activation observed	Further studies required
Galidesivir	RNA polymerase inhibitor	Preclinical	Effective in animal models	Human trials needed
Remdesivir	Antiviral drug	Preclinical	Shows potential in vitro	Further evaluation required