Marburg virus disease: Emerging threat, pathogenesis, and global public health strategies

Table 4 Phases of Marburg virus with symptoms

Incubation Period (5–10 days)
Phase	Duration	Key symptoms	Outcome	Treatment
Generalization phase	Days 1–4	Fever (39–40 °C), headache, chills, myalgia, anorexia. Gastrointestinal symptoms like nausea, vomiting, diarrhoea	Supportive care may prevent progression	Galidesivir (BCX4430)
Early organ phase	Days 5–13	Hemorrhagic symptoms (petechiae, mucosal bleeding), maculopapular rash, fatigue, organ damage (kidney, liver)	Escalation in disease severity	Favipiravir (T-705), Obeldesivir
Late organ phase/convalescence phase	Days 13+	Recovery: Gradual resolution of symptoms. Fatality: Multiorgan failure, shock, dehydration	Recovery or death within 8–16 days	Remdesivir (GS-5734), AVI-7288