Micro RNAs as a potential biomarker for predicting liver fibrosis severity in hepatitis C virus affected patients

Table 3 Expression of miRNAs and other non-invasive markers in hepatitis C virus cases

	No fibrosis (n = 25)		Mild (n = 24)		Moderate (n = 25)		Severe (n = 26)		P value
	Mean	SD	Mean	SD	Mean	SD	Mean	SD
Hb	12.79	2.33	12.73	2.48	12.36	2.37	12.06	2.41	0.674
INR	1.11	0.18	1.21	0.23	1.15	0.21	1.15	0.21	0.478
TSP	6.77	0.65	6.89	0.41	6.91	0.64	6.95	0.50	0.683
Albumin	3.95	0.61	3.80	0.63	3.87	0.59	3.84	0.56	0.849
Bilirubin	0.63	0.45	0.71	0.27	0.68	0.32	0.78	0.37	0.488
AST	48.92	22.21	72.96	52.12	99.92	48.72	137.88	100.97	0.000
ALT	59.40	34.72	85.43	84.73	112.56	71.68	127.69	73.42	0.003
ALP	85.28	11.89	83.00	8.52	112.16	22.44	145.19	31.32	0.000
TLC	8584.00	1182.05	7987.50	1375.66	7304.00	1347.37	7203.85	1076.10	0.000
Plt. Cnt. (X1000MM3)	226.56	92.48	194.08	72.86	166.44	61.72	137.27	45.06	0.000
miR122	1.10	0.97	2.32	1.97	6.90	5.66	15.65	13.81	0.000
miR155	1.34	1.17	3.75	3.22	10.09	7.56	7.92	7.44	0.000
miR199a	1.53	1.73	0.36	0.37	0.07	0.07	0.02	0.02	0.000
miR21	0.93	0.92	2.40	1.77	6.52	4.24	16.97	17.77	0.000

Hb: Hemoglobin; INR: International normalized ratio; TSP: Total serum protein; AST: Aspartate transaminase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase TLC: Total leukocyte count; HCV: Hepatitis C virus.