Delivery strategies for novel vaccine formulations

Figure 2 Schematic image of the E2 acetyltransferase display system derived from the Bacillus stearothermophilus pyruvate dehydrogenase complex. A: The E2 chain as it occurs in the native pyruvate dehydrogenase complex. Twenty trimers of the E2 polypeptide chain form a pentagonal dodecahedron (60-mer) with icosahedral symmetry; B: Representation of the E2 core displaying the HIV-1 Envelope (Env) third hypervariable region V3 on the surface of the scaffold. LIP: Lypoil domain; PSBD: Peripheral subunit-binding domain; CD: Catalytic domain; E2DISP: E2 acetyltransferase display system.