Guidelines For Clinical Practice
Copyright ©2012 Baishideng Publishing Group Co.
World J Virol . Feb 12, 2012; 1(1): 23-30
Published online Feb 12, 2012. doi: 10.5501/wjv.v1.i1.23
Table 1 Porcine reproductive and respiratory syndrome virus genome and relevant information
ORFProductFunctionRole in immunity/protectionRef.
1aNsp1αPapain-like cysteine proteasePotential IFN and TNFα antagonist[66-68]
Nsp1βPapain-like cysteine proteasePotential IFN and TNFα antagonist[66,68,69]
Nsp2Cysteine proteasePotential IFN antagonist[70]
Nsp3Transmembrane proteinNA[70]
Nsp4Serine proteaseNA[70]
Nsp5Transmembrane proteinNA[70]
Nsp6NANA[70]
Nsp7αNAPotential antigen for serological determination of persistence infection[70]
Nsp7βNAPotential antigen for serological determination of persistence infection[70]
Nsp8NANA[70]
1bNsp9RNA-dependent RNA polymeraseNA[70]
Nsp10HelicaseNA[70]
Nsp11EndoribonucleasePotential IFN antagonist[70,71]
Nsp12NANA[70]
2aGP2Minor envelope protein; interacts with CD163Minor neutralizing epitope[72]
2bE proteinMinor envelope protein; possibly form oligomeric ion channelNA[72]
3GP3Minor envelope proteinMinor neutralizing epitope[72]
4GP4Minor envelope protein; interacts with CD163Minor neutralizing epitope[72]
5GP5Major envelope protein; interacts with sialoadhesinMajor neutralizing epitope[72]
6M proteinMajor envelope protein; interacts with heparan sulfateT cell epitope; minor neutralizing epitope[72]
7N proteinNucleocapsidNon-neutralizing epitope[72]