Total pancreatectomy and islet autotransplantation: A decade nationwide analysis

Table 1 Demographics and clinical characteristics of patients who underwent total pancreatectomy and islet autotransplantation

Variables		TP and islet auto-transplantation (sample size = 754)
Age	Mean ± SD (yr)	39 ± 13
	Median (yr)	41
Sex	Female	513 (68%)
Race	White	260/295 (88%)1
	Black or African American	20/295 (6.7%)1
	Hispanic	5/295 (1.6%)1
	Asian	5/295 (1.6%)1
	Other	5/295 (1.6%)1
Comorbidity	Diabetes mellitus	202 (26.8%)
	Hypertension	188 (25%)
	Deficiency anemia	153 (20.4%)
	Chronic pulmonary disease	98 (13.1%)
	Drug abuse	88 (11.7%)
	Coagulopathy	63 (8.3%)
	Alcohol abuse	44 (5.9%)
	Obesity	25 (3.3%)
	Weight loss	22 (29.l3%)
Admission type	Elective	660 (87.7%)
	Non-elective	93 (12.3%)
Patient diagnosis/indication of surgery	Chronic pancreatitis	648 (86%)
	Acute pancreatitis	90 (12%)
	Other diagnosis	15 (2.1%)
Other factors	Preoperative fluid and electrolyte disorders	216 (28.7%)

¹Race data are available only for 295 patients from nationwide inpatient sample database.

Table 2 Postoperative complications of patients who underwent total pancreatectomy and islet autotransplantation

Complications	Rate
Mortality	0 (0%)
Overall morbidity	435 (57.8%)
Post surgical hypoinsulinemia	318 (42.3%)
Acute renal failure	90 (12%)
Wound infection	63 (8.4%)
Pneumonia	56 (7.4%)
Hemorrhagic complications	50 (6.6%)
Peritoneal abscess	34 (4.5%)
Thrombosis of portal vein	25 (3.3%)
Acute myocardial infarction	15 (2%)
Wound disruption	14 (1.9%)
Acute respiratory failure	10 (1.3%)
Thromboembolic complications	10 (1.3%)
Deep vein thrombosis	1
Biliary stricture	1

¹Too small to report.

Table 3 Risk adjusted analysis of morbidity predictors of patients who underwent total pancreatectomy and islet autotransplantation (multivariate analysis)

Variables		Adjusted odds ratio	95%CI	P value
Age	Age	1.01	1.01-1.02	0.82
Sex	Female	1.95	1.30-2.94	< 0.01
Comorbidity	Diabetes mellitus	1.06	0.68-1.63	0.78
	Hypertension	0.70	0.45-1.08	0.11
	Deficiency anemia	0.85	0.57-1.27	0.43
	Chronic pulmonary disease	0.56	0.34-0.91	0.19
	Drug abuse	0.55	0.33-0.93	0.27
	Coagulopathy	1.24	0.63-2.44	0.52
	Alcohol abuse	2.63	1.23-5.63	0.01
	Obesity	3.02	1.00-9.11	0.049
	Weight loss	2.43	1.64-3.60	< 0.01
Other factors	Preoperative fluid and electrolyte disorders	2.71	1.79-4.09	< 0.01