Preservation solutions used during abdominal transplantation: Current status and outcomes

Table 1 Comparison of select preservation solutions

	Euro-Collins	University of Wisconsin	Histidine-tryptophan-ketoglutarate	Celsior
Intracellular/extracellular	Intracellular	Intracellular	Extracellular	Extracellular
Sodium	10	25	15	100
Potassium	115	120	10	15
Impermeant	Glucose	Lactobionate	Mannitol	Lactobionate
	Mannitol	Raffinose		Mannitol
		Hydroxyethyl starch
Buffer	Phosphate	Phosphate	Histidine	Histidine
	Bicarbonate
Antioxidant	Mannitol	Allopurinol	Tryptophan	Glutathione
		glutathione	Mannitol	Mannitol
			Histidine	Histidine
Energy precursor	---	Adenosine	Glutamic acid/glutamate	Glutamic acid/glutamate
Others		Insulin	Ketoglutarate
		Dexamethasone

All units expressed in mmol/L.

Table 2 Selected clinical studies involving liver preservation solutions

Ref.	Solution	Cases	Patient survival	Graft survival
UW vs HTK
Erhard et al[43]	UW vs HTK	60 (UW 30, HTK 30)	No diff (30 mo)	No diff (3 mo)
			(UW 74%, HTK 77%)	(UW 80%, HTK 87%)
Mangus et al[44]	UW vs HTK	378 (UW 204, HTK 174)	No diff (1 yr)	No diff (1 yr)
			(UW 84.6%, HTK 82.1%)	(UW 81.7%, HTK 80.8%)
Rayya et al[45]	UW vs HTK	137 (UW 68, HTK 69)	No diff (1 yr)	No diff (1 yr)
			(UW 78%, HTK 78%)	(UW 78%, HTK 71%)
Mangus et al[51]	UW vs HTK	698 (UW 327, HTK 371)	No diff (1 yr)	No diff (1 yr)
			(UW 88%, HTK 87%)	(UW 84%, HTK 86%)
Avolio et al[46]	UW vs HTK	39 (UW 22, HTK 17)	No diff (not stated)	No diff (6 mo)
			(UW 82%, HTK 88%)	(UW 80.9%, HTK 85.7%)
Canelo et al[47]	UW vs HTK	134 (UW 71, HTK 63)	No diff	No diff
Celsior vs (HTK or UW)
Nardo et al[57]	CEL vs HTK	40 (CEL 20, HTK 20)	No diff (1 yr)	No diff (1 yr)
			(CEL 90%, HTK 85%)	(CEL 90%, HTK 75%)
García-Gil et al[56]	CEL vs UW	80 (CEL 40, UW 40)	No diff (1 yr)	No diff (1 yr)
			(CEL 85.7%, UW 79.8%)	(CEL 78%, UW 75.5%)
Cavallari et al[55]	CEL vs UW	173 (CEL 83, UW 90)	No diff (1 yr)	No diff (1 yr)
			(CEL 87%, UW 89%)	(CEL 85%, UW 83%)
Lopez-Andujar et al[53]	CEL vs UW	196 (CEL 92, UW 104)	No diff (1 yr)	No diff (1 yr)
			(CEL 83%, UW 83%)	(CEL 81%, UW 80%)
Pedotti et al[54]	CEL vs UW	175 (CEL 79, UW 96)	No diff (1 yr)	No diff (1 yr)
			(CEL 89.9%, UW 90.6%)	(CEL 83.3%, UW 85.4%)

Diff: Difference; UW: University of Wisconsin; CEL: Celsior; HTK: Histidine-tryptophan-ketoglutarate.

Table 3 Selected clinical studies involving renal preservation solutions

Ref.	Solution	Cases	Patient survival	Graft survival
UW solution vs HTK solution
Lynch et al[60]	UW vs HTK	Living donor = 950 (UW 475, HTK 475)	No diff (1 yr)	No diff (1 yr)
		Deceased donor = 634	(living or deceased donors)	(Living or deceased donors)
		(UW 317, HTK 317)
de Boer et al[61]	UW vs HTK	611 (UW 297, HTK 314)	----	No diff (1 yr)
				(UW 81%, HTK 83%)
Klaus et al[62]	UW vs HTK	51 (UW 27, HTK 24)	No diff (1 yr)	No diff (1 yr)
			(UW 84% vs HTK 86%)	(UW 78%, HTK 79%)
UW solution vs CEL solution
Montalti et al[64]	UW vs CEL	50 (UW 25, CEL 25)	No diff (1 yr)	No diff (1 yr)
			(UW 100%, CEL 100%)	(UW 96%, CEL 91.8%)
				P value not stated
Faenza et al[23]	UW vs CEL	187 (UW 88, CEL 99)	No diff (2 yr)	No diff (2 yr)
			(UW 100%, CEL 100%)	(UW 75%, CEL 84%)
				P value not stated
Pedotti et al[54]	UW vs CEL	441 (UW 269, CEL 172)	No diff (1 yr)	No diff (1 yr)
			(UW 97.7%, CEL 99.4%)	(UW 91%, CEL 94.2%)
			P value not stated	P value not stated
EC solution vs HTK solutions
de Boer et al[61]	EC vs HTK	569 (EC 277, HTK 292)	----	No diff (1 yr)
				(EC 78%, HTK 80%)
				P value not stated

Diff: Difference; UW: University of Wisconsin; CEL: Celsior; HTK: Histidine-tryptophan-ketoglutarate; EC: Euro-Collins.

Table 4 Selected clinical studies involving pancreas preservation solutions

Ref.	Solution	Cases	Patient survival	Graft survival
UW solution vs HTK solution
Potdar et al[68]	UW vs HTK	33 (UW 17, HTK 16)	No diff (30 d)	No diff (30 d)
			(UW 100%, HTK 100%)	(UW 100%, HTK 94%)
Englesbe et al[69]	UW vs HTK	75 (UW 41, HTK 36)	No diff (90 d)	No diff (90 d)
			(UW 100%, HTK 100%)	(UW 90.2%, HTK 86%)
Schneeberger et al[70]	UW vs HTK	68 (UW 41, HTK 27)	No diff (6 mo)	No diff (6 mo)
			(100% UW and HTK 96.3%)	(90.2% UW, 85.2% HTK)
Becker et al[71]	UW vs HTK	95 (UW 47, HTK 48)	No diff (1 yr)	No diff (1 yr)
			(UW 89.4% and HTK 95.7%)	(UW 82.6%, HTK 85.4%)
Agarwal et al[72]	UW vs HTK	87 (UW 10, HTK 78)	No diff (1 yr)	No diff (1 yr)
			(UW 100% and HTK 93%)	(UW 100% and HTK 92%)
Alonso et al[74]	UW vs HTK	97 (UW 81, HTK 16)	No diff (3 yr)	No diff (3 yr)
UW solution vs CEL solution
Manrique et al[77]	UW vs CEL	72 (UW 44, HTK 28)	No diff (2 yr)	No diff (2 yr)
			(UW 94.7%, CEL 84.4%)	(UW 74.6%, CEL 77.4%)
Boggi et al[25]	UW vs CEL	100 (UW 50, HTK 50)	No diff (1 yr)	No diff (1 yr)
			(UW 98.0%, CEL 98.0%)	(UW 95.8%, CEL 95.9%)

Diff: Difference; UW: University of Wisconsin; CEL: Celsior; HTK: Histidine-tryptophan-ketoglutarate.