Efficacy and safety of non-vitamin K antagonist oral anticoagulants post-kidney transplantation

Table 3 Profile of the cases that developed bleeding

	Case 1	Case 2	Case 3
Age	77	73	87
Gender	Male	Female	Female
NOACs on use	Rivaroxaban	Apixaban	Apixaban
NOACs dose	15mg daily	2.5mg bid	2.5mg bid
Type of bleeding	Major	Non-major	Non-major
Site of bleeding	Intra-ocular	Bleeding per rectum	Bleeding per rectum
Time to bleed	> 1 yr post starting	> 1 yr post starting	> 1 yr post starting
Base line Cr/eGFR	93/72.6	67/79.5	122/38.44
Cr/eGFR at bleeding	144/38.6	58/93.9	147/31.0
CNI in use	Cyclosporin	Tacrolimus	Cyclosporin
CNI level at bleeding time	C0: 91	5.8 (within target)	C0: 116
Antiplatelet used	None	None	None
note	Rivaroxaban was on hold at the time of bleeding. Bled post cataract surgery.

NOACs: Novel oral anticoagulants; CR: Creatinine; eGFR: Estimated glomerular filtration rate; CNI: Calcineurin inhibitors.