Hepatitis C and renal transplantation in era of new antiviral agents

Table 6 European Association for the Study of the Liver Recommendations for treating hepatitis C virus in patients with reduced or absent renal function

Hemodialysis patients, particularly those who are suitable candidates for renal transplantation, should be considered for antiviral therapy (B1)

Hemodialysis patients should receive an IFN-free, if possible ribavirin-free regimen, for 12 wk in patients without cirrhosis, for 24 wk in patients with cirrhosis (B1)

Simeprevir, daclatasvir, and the combination of ritonavir-boosted paritaprevir, ombitasvir and dasabuvir are cleared by hepatic metabolism and can be used in patients with severe renal disease (A1)

Sofosbuvir should not be administered to patients with an eGFR < 30 mL/min per 1.73 m2 or with end-stage renal disease until more data is available (B2)