Biomarkers in renal transplantation: An updated review

Table 12 Immune/inflammatory molecules among the 357 gene signatures of tolerance

Categories	Diseases or functions annotation	Molecules	No. of molecules
Cell-to-cell signaling and interaction, cellular function and maintenance, hematological system development and function, inflammatory response	Phagocytosis of leukocyte cell lines	FGR, MRC1, TLR4	3
Cell-to-cell signaling and interaction, hematological system development and function, immune cell trafficking, inflammatory response, tissue development	Binding of neutrophils	FGR, LSP1, TLR4	3
Antimicrobial response, inflammatory response	Antibacterial response	CARD9, FGR, LYST, NLRC4, TLR4	5
Cell-to-cell signaling and interaction, hematological system development and function, inflammatory response	Binding of professional phagocytic cells	FGR, LSP1, NOTCH2, TLR4	4
Inflammatory response	Immune response of cells	CARD9, CLEC7A, ETS2, FGR, MRC1, SCARF1, MYO7A, TLR4	8
Antimicrobial response, inflammatory response	Antimicrobial response	CARD9, CLEC7A, FGR, LYST, NLRC4, TLR4	6
Inflammatory response	Innate immune response	CARD9, CLEC7A, TLR4, TRIM59	4
Cellular function and maintenance, inflammatory response	Phagocytosis	CLEC7A, ETS2, FGR, MRC1, MYO7A, TLR4, TPCN2	7
Cell-to-cell signaling and interaction, cellular growth and proliferation, hematological system development and function, inflammatory response	Stimulation of phagocytes	IL4R, TLR4	2
Antimicrobial response, humoral immune response, inflammatory response	Antifungal response	CARD9, CLEC7A	2
Cell-to-cell signaling and interaction, cellular function and maintenance, inflammatory response	Phagocytosis of cells	CLEC7A, ETS2, FGR, MRC1,MYO7A, TLR4	6

These genes potentially predict those patients that can be successfully weaned off immunosuppression[133]. FGR: Tyrosine-protein kinase Fgr; MRC1: Mannose receptor, C type 1; TLR4: Toll-like receptor 4; FGR: Tyrosine-protein kinase Fgr; LSP1: Lymphocyte-specific protein 1; CARD9: Caspase recruitment domain family member 9; LYST: Lysosomal-trafficking regulator; NLRC4: NLR family CARD domain-containing protein 4; NOTCH2: Neurogenic locus notch homolog protein 2; CLEC7A: C-type lectin domain family 7 member A; ETS2: Protein C-ets-2; SCARF1: Scavenger receptor class F member 1; MYO7A: Unconventional myosin-VIIa; TRIM59: Tripartite motif-containing protein 59; TPCN2: Two pore calcium channel protein 2; IL4R: Interleukin 4 receptor.