Risk factors for fracture in adult kidney transplant recipients

Table 4 Univariable and multivariable analysis of risk factors for other fracture in kidney transplant recipients

Risk factor	Univariable analysis	Multivariable analysis
	HR (95%CI)	HR (95%CI)
Age (per 5 yr increase)	1.09 (1.02-1.17)	1.03 (0.96-1.10)
Sex
Men	Reference
Women	0.99 (0.63-1.26)	0.97 (0.68-1.39)
Race/ethnicity
White	Reference
Asian	0.67 (0.33-1.37)	0.67 (0.32-1.39)
Black	0.59 (0.27-1.26)	0.47 (0.21-1.02)
Other1	0.82 (0.49-1.39)	0.73 (0.43-1.26)
Diabetes (vs none)	2.2 (1.57-3.08)	2.19 (1.38-3.49)
Fall with hospitalization in the year prior to the transplant date (vs none)	2.37 (1.25-4.52)	2.05 (1.07-3.93)
Length of time on dialysis prior to transplant (measured in years)2	1.06 (1.00-1.12)	1.07 (1.01-1.14)
Type of donor
Living	Reference
Deceased	0.67 (0.47-0.92)
Cause of end-stage renal disease
Glomerulonephritis	Reference	Reference
Cystic kidney disease	1.4 (0.8-2.47)	1.35 (0.76-2.39)
Diabetes	2.47 (1.56-3.91)	1.40 (0.78-2.49)
Renal vascular disease	2.40 (1.41-4.10)	2.11 (1.22-3.65)
Other	2.04 (1.21-3.44)	2.03 (1.20-3.45)
Pre-transplant dialysis modality3
Hemodialysis	Reference
Peritoneal dialysis	1.06 (0.74-1.53)
Pre-emptive	0.43 (0.2-0.92)
Donor age (per 5 yr increase)	1.07 (1.01-1.14)	1.06 (0.99-1.12)
Donor sex
Men	Reference
Women	0.83 (0.6-1.16)

¹Other was defined as a composite of: Indian Sub-Continent, Pacific Islander, Aboriginal, Mid East/Arabian, Latin American, Other/Multiracial;

²Includes individuals who received a pre-emptive transplant where the time spent on dialysis was defined as 0 years;

³We defined hemodialysis and peritoneal dialysis based on the modality they first received. We defined pre-emptive transplant as no evidence of hemodialysis or peritoneal dialysis prior to transplant.