Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation

Table 6 Effect of removal of the pump delivering castanospermine on blood level of cyclosporin A

Blood level of CsA1
CsA dose2	On pump	Castanospermine dose2	No.	Mean	SD
23	Yes	0	10	333.10	167.84
		100	10	313.20	83.06
		200	10	296.60	122.98
	No	0	5	513.20	170.76
		100	5	560.00	254.00
		200	5	355.40	105.29
34	Yes	0	10	791.20	352.83
		100	10	617.50	239.87
		200	8	473.13	209.79
	No	0	5	849.40	455.77
		100	5	671.20	421.57
		200	4	824.50	153.44
44	Yes	0	10	911.00	295.81
		100	10	876.80	313.14
		200	10	793.90	340.42
	No	0	5	968.80	429.26
		100	5	1188.60	453.13
		200	5	589.40	290.93

¹CsA levels are given in μmol/L;

²CsA and CAST doses are given in mg/kg per day body weight;

³Off pump significantly increased compared with on pump (P = 0.02);

⁴No significant difference between on pump vs off pump values. CAST: Castanospermine; CsA: Cyclosporin A.