Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation

Table 5 Effect of the dose of castanospermine delivered by a pump on the blood level of cyclosporin A

Blood level of CsA1
CsA dose2	d	Castanospermine dose2	No.	Mean	SD
23,4	3	0	5	189.2	73.34
	3	100	5	299.8	53.53
	3	200	5	313.0	131.56
	6	0	5	477.0	78.97
	6	100	5	326.6	110.48
	6	200	5	280.2	126.69
33,5	3	0	5	520.6	177.18
	3	100	5	450.2	218.76
	3	200	4	506.5	271.96
	6	0	5	1061.80	256.22
	6	100	5	784.80	107.83
	6	200	4	439.75	160.51
43,6	3	0	5	711.80	184.61
	3	100	5	601.40	121.33
	3	200	5	1031.60	287.18
	6	0	5	1110.20	252.20
	6	100	5	1152.20	127.67
	6	200	5	556.20	192.41

¹CsA levels are given in μmol/L;

²CsA and CAST doses are given in mg/kg per day body weight;

³No significant increase in CsA level for no CAST vs CAST at day 3 or day 6;

⁴For each CsA dose the difference in trend of day 6 values compared with day 3 was significant: CsA 2 mg/kg per day P = 0.02;

⁵CsA 3 mg/kg per day P = 0.04;

⁶CsA 4 mg/kg per day P = 0.001. CAST: Castanospermine; CsA: Cyclosporin A.