Copyright
©2013 Baishideng Publishing Group Co.
World J Transplant. Jun 24, 2013; 3(2): 7-25
Published online Jun 24, 2013. doi: 10.5500/wjt.v3.i2.7
Published online Jun 24, 2013. doi: 10.5500/wjt.v3.i2.7
Table 8 Calcineurin inhibitors avoidance trials
| Study (yr) | Drugs | F-Up(mo) | Patient survival | Graft survival | Biopsy provenAcute rejection | Glomerular filtration rate (mL/min) | ||||
| SRL | CNI | SRL | CNI | SRL | CNI | SRL | CNI | |||
| Flechner (2004) | SRL/CsA | 24 | 93.50% | 100% | 93.50% | 93.60% | 6.50% | 16.60% | 60.6 | 49.2 |
| Flechner (2007) | SRL/CsA | 60 | 87.10% | 90% | 83.90% | 76.70% | 12.90% | 23.30% | 66.7 | 50.7 |
| Larson (2006) | SRL/TAC | 12 | 98.00% | 96% | 94% | 92% | 13% | 10% | 63 | 61 |
| SYMPHONY (2007) | SRL/CsA | 36 | 95% | 94% | 85% | 87% | 39% | 27% | 71.1 | 67.1 |
| Hamdy (2008 ) | SRL/TAC | 60 | 98.50% | 93.80% | 88% | 83% | NA | NA | 89 | 93 |
| Lo (2004) | SRL/TAC | 12 | 100% | 98% | 89% | 80% | 7% | 10% | 72.4 | 50.5 |
| Ruggenenti (2007) | SRL/CsA | 24 | NA | NA | NA | NA | NA | NA | 52 | 49.8 |
| Spiesser Group (2007) | SRL/TAC | 12 | 97% | 97% | 90% | 93% | 14.30% | 8.60% | 69 | 60 |
| Glotz (2010) | SRL/TAC | 12 | 95.80% | 97.10% | 85.90% | 95.70% | 16.90% | 12.90% | 56.1 | 58.4 |
| ORION (2011) | SRL/TAC | 24 | 94.5% | 97% | 89.9% | 95.4% | 32.8% | 12.3% | 63.4 | 66.7 |
- Citation: Salvadori M, Bertoni E. Is it time to give up with calcineurin inhibitors in kidney transplantation? World J Transplant 2013; 3(2): 7-25
- URL: https://www.wjgnet.com/2220-3230/full/v3/i2/7.htm
- DOI: https://dx.doi.org/10.5500/wjt.v3.i2.7