Is it time to give up with calcineurin inhibitors in kidney transplantation?

doi:10.5500/wjt.v3.i2.7

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Jun 24, 2013; 3(2): 7-25
Published online Jun 24, 2013. doi: 10.5500/wjt.v3.i2.7

Table 3 Selected randomized trials on calcineurin inhibitors minimization

Study (yr)	Intervention arm	Control arm	CNI minimization	Study lenght (mo)
Andres (2009)	IL2Ri + lCsA + MMF + S	IL2Ri + lowCsA + MMF + S	Minimization	6
US09 (2008)	IL2Ri + EVR + lowTAC + S	IL2Ri + EVR + TAC + S	Minimization	6
Ciancio (2005)	Alem + lowTAC + lowMMF	rATG + TAC + MMF + S	Minimization	12
De Sevaux (2001)	lowCsA + MMF + S	CsA + MMF + S	Minimization	6
CAESAR (2007)	IL2Ri +lowCsA + MMF + S	CsA + MMF + S	Minimization	12
ELITE SYMPHONY (2007)	DAC+lTAC/lCsA/SRL+MMF+S	DAC+sCsA+MMF+S	Minimization	36
OptiCept (2009	Induction + lowCNI +MMF + S	Induction + CNI + MMF + S	Minimization	24
Hernandez (2007)	IL2Ri + lowCsA + MMF + S	IL2Ri + CsA + MMF + S	Mimimization	24
Kandaswamy (2005	rATG + lowTAC + S	rATG + TAC + S	Minimization	24
RADB156 (2004)	IL2Ri + lowCsA + EVR + S	IL2Ri + CsA+ EVR + S	Minimization	36
EVEREST (2009	standEVR + lowCsA +S	HighEVR + vlowCsa +S	Minimization	36
Vathsala (2005)	Alem + lowCsA	CsA + AZA + S	Minimization	6
ASSET (2012 )	EVR + lowTAC	EVR + vlowTAC	Minimization	12

rATG: Rabbit Antithymocyte globuline; Alem: Alemtuzumab; CNI: Calcineurin inhibitor; CsA: Cyclosporine; EVR: Everolimus; TAC: Tacrolimus; DAC: Daclizumab; IL2Ri: Interleukin 2 receptor inhibitors; MMF : Mycophenolate mofetil; S: Steroids.

Citation: Salvadori M, Bertoni E. Is it time to give up with calcineurin inhibitors in kidney transplantation? World J Transplant 2013; 3(2): 7-25
URL: https://www.wjgnet.com/2220-3230/full/v3/i2/7.htm
DOI: https://dx.doi.org/10.5500/wjt.v3.i2.7