Impact of pretransplant donor-specific antibodies and human leukocyte antigen mismatches on graft and patient outcomes: A cohort from Saudi Arabia

doi:10.5500/wjt.122485

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Transplant. Sep 18, 2026; 16(3): 122485
Published online Sep 18, 2026. doi: 10.5500/wjt.122485

Table 7 Clinical and immunological profiles by rejection group

Group	n	Median HLA mismatches	Median LOS	DSA class profile	Median DSA count	Median DSA MFI	Sensitizing events (%)	Graft loss (%)
DSA+ AMR	2	8.0	8.5 days	Both	3.5	4121.0	50.0	0.0
DSA+ mixed	3	9.0	8.0 days	Both, Class II	1.0	2010.0	33.3	100.0
DSA+ TCMR	2	8.5	8.5 days	Both, Class I	1.0	4100.5	50.0	0.0
DSA- TCMR	3	9.0	9.0 days	-	-	-	0.0	0.0

AMR: Antibody-mediated rejection; DSA: Donor-specific antibody; HLA: Human leukocyte antigen; LOS: Length of stay; MFI: Mean fluorescence intensity; TCMR: T cell-mediated rejection.

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Citation: Al-Qurashi SH, Khalil MAM, Mahmood HHK, Altom AA, Alqurashi YF, Alsaedi ZA, Cruz AJD, Alsharif MM, Bawayan RM, Housawi AA, Sadagah NM. Impact of pretransplant donor-specific antibodies and human leukocyte antigen mismatches on graft and patient outcomes: A cohort from Saudi Arabia. World J Transplant 2026; 16(3): 122485
URL: https://www.wjgnet.com/2220-3230/full/v16/i3/122485.htm
DOI: https://dx.doi.org/10.5500/wjt.122485

Al-Qurashi SH, Khalil MAM, Mahmood HHK, Altom AA, Alqurashi YF, Alsaedi ZA, Cruz AJD, Alsharif MM, Bawayan RM, Housawi AA, Sadagah NM. Impact of pretransplant donor-specific antibodies and human leukocyte antigen mismatches on graft and patient outcomes: A cohort from Saudi Arabia. World J Transplant 2026; 16(3): 122485 [DOI: 10.5500/wjt.122485]

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