Impact of pretransplant donor-specific antibodies and human leukocyte antigen mismatches on graft and patient outcomes: A cohort from Saudi Arabia

doi:10.5500/wjt.122485

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Transplant. Sep 18, 2026; 16(3): 122485
Published online Sep 18, 2026. doi: 10.5500/wjt.122485

Table 6 Kidney transplant rejection summary

ID.	Tx type	Tx date	Rejection type(s)	Rejection date(s)	Time post-Tx	Banff grade	C4d status	SV40	Primary disease	DSA	HLA mismatch	Class I antibodies	Class II antibodies
29	LRRT	April 26, 2021	Acute AMR	May 12, 2021	2 weeks	-	Inconclusive	Negative	Unknown	Positive	7	AntiC (1091.0)	AntiDR (615)
41	LRRT	June 13, 2021	Acute TCMR/Acute AMR	July 5, 2021/July 19, 2021	3 weeks/1 month	Type IIB	Negative	Negative	Unknown	Positive	11	AntiA (879.0) \| AntiC (985.0)	AntiDR (905+561) \| AntiDQ (567.0)
47	ERRT	September 20, 2021	Mixed acute TCMR/CAAMR	April 27, 2023/April 8, 2024	1.5 years	Type IB	Positive	Negative	Unknown	Positive	9	AntiC (1290.0)	AntiDQ (720.0)
118	LRRT	September 29, 2022	Acute TCMR	September 18, 2024	2 years	Type IB	Negative	Negative	Unknown	Negative	9	-	-
113	LURT	November 5, 2022	Acute TCMR	November 29, 2022	3 weeks	Type IIB	Negative	Negative	Unknown	Positive	8	AntiB (647.0) \| AntiC (3027.0)	AntiDR (1022+699+902) \| AntiDP (1227)
161	LRRT	June 12, 2023	Acute TCMR	August 13, 2023	2 months	Borderline	Negative	Negative	Unknown	Positive	9	AntiC (677.0)	-
171	LRRT	July 15, 2023	Acute TCMR	January 25, 2024	6 months	Type IA	Negative	Negative	Unknown	Negative	11	-	-
225	DDRT	May 11, 2024	Acute AMR	June 5, 2024	1 month	-	Focally positive	Not done	FSGS	Positive	9	AntiA (4641.0)	AntiDR (707) \| AntiDP (559.0) \| AntiDQ (629.0)
44	LRRT	June 28, 2021	Acute TCMR	January 28, 2025	3.5 years	-	Negative	Negative	Lupus Nephritis	Negative	6	-	-
104	LRRT	October 6, 2022	Mixed Acute TCMR/AMR	May 27, 2025	2.5 years	Type IB, ptc 2-3	Negative	Negative	FSGS/SCD	Positive	7	-	AntiDR (616)

AMR: Antibody-mediated rejection; ATG: Antithymocyte globulin; CAAMR: Chronic active antibody-mediated rejection; DSA: Donor-specific antibody; DDRT: Deceased donor renal transplant; eGFR: Estimated glomerular filtration rate; ERRT: Emotionally related renal transplant; FSGS: Focal segmental glomerulosclerosis; HLA: Human leukocyte antigen; IQR: Interquartile range; IVIG: Intravenous immunoglobulin; LRRT: Living related renal transplant; LURT: Living unrelated renal transplant; MFI: Mean fluorescence intensity; MMF: Mycophenolate mofetil; OR: Odds ratio; Pred: Prednisolone; SCD: Sickle cell disease; SV40: Simian virus 40; TCMR: T-cell-mediated rejection.

Full Size Table

Citation: Al-Qurashi SH, Khalil MAM, Mahmood HHK, Altom AA, Alqurashi YF, Alsaedi ZA, Cruz AJD, Alsharif MM, Bawayan RM, Housawi AA, Sadagah NM. Impact of pretransplant donor-specific antibodies and human leukocyte antigen mismatches on graft and patient outcomes: A cohort from Saudi Arabia. World J Transplant 2026; 16(3): 122485
URL: https://www.wjgnet.com/2220-3230/full/v16/i3/122485.htm
DOI: https://dx.doi.org/10.5500/wjt.122485

Al-Qurashi SH, Khalil MAM, Mahmood HHK, Altom AA, Alqurashi YF, Alsaedi ZA, Cruz AJD, Alsharif MM, Bawayan RM, Housawi AA, Sadagah NM. Impact of pretransplant donor-specific antibodies and human leukocyte antigen mismatches on graft and patient outcomes: A cohort from Saudi Arabia. World J Transplant 2026; 16(3): 122485 [DOI: 10.5500/wjt.122485]

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