Predictive biomarkers of early allograft dysfunction after liver transplantation: A prospective pilot study

doi:10.5500/wjt.121567

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Transplant. Sep 18, 2026; 16(3): 121567
Published online Sep 18, 2026. doi: 10.5500/wjt.121567

Table 2 Serum immunomodulatory protein levels at each timepoint for early allograft dysfunction and non-early allograft dysfunction groups among static cold storage recipients

Biomarker	Timepoint	No EAD (n = 16)	EAD (n = 8)	P value
HIF-1α	T1	341.2 (88.1, 855.8)	588.3 (76.4, 1285.7)	0.7133
	T2	520.7 (415.6, 1007.6)	1087 (608.7, 1758)	0.2207
	T3	157.9 (110, 273)	611.2 (384.7, 869.9)	0.0095
	T2-T1	171.2 (-25.8, 423.8)	430.6 (86.3, 739.7)	0.1590
IL-2Rα	T1	2492 (1684, 4685)	2080 (1357, 2781)	0.1984
	T2	1158 (803, 2226)	1402 (737.7, 1674)	0.5403
	T3	3614 (3426, 4495)	3068 (2719, 5631)	0.3798
	T2-T1	-888.9 (-3419.4, 227.7)	-654.9 (-1659.3, -267.4)	0.7133
IP-10	T1	946.8 (369.2, 1304.5)	616.6 (381.2, 716.8)	0.3272
	T2	469.5 (383.7, 686.1)	871.1 (491.2, 1897)	0.1779
	T3	920.6 (644.5, 2371)	976.8 (449.4, 1212)	0.4945
	T2-T1	-181.5 (-452.4, 145.9)	386.7 (-26.7, 1280.7)	0.0200
MCP-1	T1	476.9 (330.1, 644.9)	390.6 (352.1, 497.5)	0.4624
	T2	3251 (1276, 5205)	3317 (2136, 5470)	0.6242
	T3	451.3 (386.2, 628.9)	725.3 (517.4, 1089)	0.2046
	T2-T1	2742.4 (939.7, 4605.5)	2967 (1473, 5074)	0.5815
RANTES	T1	2258 (1108, 4669)	4557 (1407, 13462)	0.2207
	T2	3002 (765, 4140)	2209 (1284, 7100)	0.4624
	T3	525.8 (417.7, 1124.5)	349.5 (222.4, 613.8)	0.4945
	T2-T1	-486.5 (-2029.5, 1915.7)	-188.2 (-3805, 2191)	0.9512
IL-1β	T1	0.59 (0.43, 0.82)	0.42 (0.3, 0.58)	0.2724
	T2	2.6 (1.1, 4.2)	2.3 (1.2, 5.5)	0.5815
	T3	0.5 (0.47, 1.02)	0.59 (0.43, 0.82)	0.8453
	T2-T1	2.14 (0.57, 3.61)	1.74 (0.75, 4.96)	0.6056
TNF-α	T1	2.21 (1.48, 4.07)	2.3 (1.8, 2.8)	1.000
	T2	4.1 (2.6, 17.1)	5.4 (3.3, 8.2)	0.6682
	T3	3.8 (2.2, 8.7)	3.9 (2.3, 6.1)	0.9223
	T2-T1	1.3 (0.35, 11.3)	2.59 (0.96, 5.6)	0.8065
MIG	T1	162.6 (95.5, 224.5)	127.1 (90.5, 142.4)	0.3272
	T2	320.5 (221.4, 501.5)	511.2 (348.1, 1022.5)	0.1258
	T3	473.3 (193.7, 593.4)	578.9 (194.1, 1269)	0.5582
	T2-T1	171.5 (83.6, 313.4)	414.7 (239.9, 898)	0.0662
IL-8	T1	28.1 (19.7, 123.9)	75.3 (11.5, 126.4)	0.8065
	T2	375.7 (79.9, 731.8)	457.9 (274.5, 1708)	0.2446
	T3	40.9 (29, 58.5)	117.7 (46.4, 164.8)	0.1432
	T2-T1	348.2 (60.5, 677.5)	387.7 (164.4, 1613.3)	0.2207
IL-6	T1	15.4 (8.7, 24.9)	6.3 (3.7, 12.9)	0.0433
	T2	95.1 (57.7, 168.3)	130.6 (96, 434.1)	0.1258
	T3	6.8 (5.9, 12.2)	8.4 (7.9, 12)	0.1432
	T2-T1	82.7 (52.1, 152.5)	121.7 (92.8, 430.3)	0.0982
PTX3	T1	26350 (16282, 46843)	19700 (13195, 74614)	0.5815
	T2	93788 (74749, 118562)	95021 (42785, 121719)	0.6242
	T3	98274 (56929, 138102)	139127 (85375, 263959)	0.0971
	T2-T1	52611 (42493, 73971)	58756.5 (16182.5, 78433.9)	0.6682
IFN-γ	T1	9.4 (5.4, 26.1)	9.6 (4.2, 11.8)	0.3745
	T2	20.2 (8.8, 38.2)	23.9 (7.3, 44.4)	0.9512
	T3	8.7 (3.4, 52.8)	9.1 (4.5, 11.1)	1.000
	T2-T1	2.8 (-1.9, 11.3)	13.14 (3.2, 29.6)	0.0982

HIF-1α: Hypoxia inducible factor-1 alpha; IL: Interleukin; IP-10: Interferon-gamma-inducible protein 10; MCP-1: Monocyte chemoattractant protein-1; RANTES: Regulated upon activation, normal T-cell expressed and secreted; IL-1β: Interleukin-1 beta; TNF-α: Tumor necrosis factor-α; MIG: Monokine induced by gamma interferon; PTX3: Pentraxin 3; IFN-γ: Interferon-gamma.

Full Size Table

Citation: Wilson EA, Rashied A, Privratsky JR, Serbanescu M, Barbas AS, Williams KM, Coopersmith CM. Predictive biomarkers of early allograft dysfunction after liver transplantation: A prospective pilot study. World J Transplant 2026; 16(3): 121567
URL: https://www.wjgnet.com/2220-3230/full/v16/i3/121567.htm
DOI: https://dx.doi.org/10.5500/wjt.121567

Wilson EA, Rashied A, Privratsky JR, Serbanescu M, Barbas AS, Williams KM, Coopersmith CM. Predictive biomarkers of early allograft dysfunction after liver transplantation: A prospective pilot study. World J Transplant 2026; 16(3): 121567 [DOI: 10.5500/wjt.121567]

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