Higher model for end-stage liver disease excluding international normalized ratio scores predict worse kidney graft outcomes in simultaneous heart-kidney transplantation

Table 1 Characteristics of recipients/donors patients with simultaneous heart–kidney transplantation stratified by model for end-stage liver disease excluding international normalized ratio score, n (%)/median (interquartile range)

Recipient characteristics	Low, n = 719	Medium, n = 1201	High, n = 228	P value
MELD-XI	16.1 (13.6-17.6)	24.8 (21.5-25.7)	27.8 (26.7-30.0)	< 0.001
Age (year)	61.0 (54.0-65.0)	57.0 (50.0-63.0)	55.0 (47.0-62.0)	< 0.001
Sex				< 0.001
Male	173 (24)	209 (17)	26 (11)
Female	546 (76)	992 (83)	202 (89)
Race
White	365 (51)	523 (44)	91 (40)
Black	237 (33)	482 (40)	95 (42)
Hispanic	72 (10)	124 (10)	21 (9.2)
Asian	27 (3.8)	52 (4.3)	13 (5.7)
Other	18 (2.5)	20 (1.7)	8 (3.5)
BMI (kg/m2)	27.1 (24.2-30.8)	27.1 (24.0-31.0)	26.6 (23.0-30.1)	0.12
Blood type				0.81
A	271 (38)	430 (36)	78 (34)
AB	35 (4.9)	72 (6.0)	14 (6.1)
B	119 (17)	205 (17)	45 (20)
O	294 (41)	494 (41)	91 (40)
Waitlist days	42 (14-166)	52 (15-190)	29 (9-79)	< 0.001
Diabetes	340 (47)	578 (48)	96 (42)	0.25
HCV serostatus
Negative	692 (96)	1180 (98)	221 (97)
Positive	27 (3.8)	21 (1.7)	7 (3.1)
Serum Cr at transplant (mg/dL)	1.70 (1.33-1.98)	3.00 (2.40-4.59)	3.55 (2.22-4.70)	< 0.001
Serum Cr at admission (mg/dL)	1.17 (0.86-1.60)	1.37 (1.00-2.00)	1.36 (0.93-2.02)	< 0.001
Dialysis at transplant
No	719 (100)	755 (63)	89 (39)
Yes	0 (0)	444 (37)	139 (61)
Total bilirubin (mg/dL)	1.00 (1.00-1.00)	1.00 (1.00-1.00)	1.70 (1.30-2.80)	< 0.001
Peripheral vascular disease	80 (11)	175 (15)	26 (11)	0.067
Intra-aortic balloon pump	169 (24)	247 (21)	39 (17)	0.088
Left ventricular assist device	272 (38)	374 (31)	72 (32)	0.009
Extracorporeal membrane oxygenation	39 (5.4)	39 (3.2)	21 (9.2)	< 0.001
Location at transplant: ICU	414 (58)	660 (55)	154 (68)	0.002
Inpatient	120 (17)	224 (19)	41 (18)
Outpatient	185 (26)	317 (26)	33 (14)
Donor characteristics
Age (year)	31.0 (23.0-39.0)	32.0 (24.0-39.0)	31.0 (25.0-39.0)	0.48
Race
White	448 (62)	716 (60)	143 (63)
Black	93 (13)	174 (14)	32 (14)
Hispanic	155 (22)	269 (22)	43 (19)
Asian	7 (1.0)	26 (2.2)	7 (3.1)
Other	16 (2.2)	16 (1.3)	3 (1.3)
Blood type
A	245 (34)	395 (33)	68 (30)
AB	14 (1.9)	30 (2.5)	5 (2.2)
B	79 (11)	131 (11)	31 (14)
O	381 (53)	645 (54)	124 (54)
BMI (kg/m2)	27.1 (23.7-30.7)	26.9 (23.5-30.9)	26.5 (23.4-30.6)	0.5
Creatinine (mg/dL)	0.90 (0.70-1.20)	0.90 (0.70-1.17)	0.90 (0.73-1.20)	0.29
Cause of death
Anoxia	299 (42)	480 (40)	81 (36)
Cerebrovascular	93 (13)	157 (13)	32 (14)
Trauma	314 (44)	530 (44)	109 (48)
Other	13 (1.8)	27 (2.2)	6 (2.6)
DCD				0.29
No	682 (95)	1145 (95)	222 (97)
Yes	37 (5.1)	56 (4.7)	6 (2.6)
Kidney pump
No	409 (57)	657 (55)	134 (59)
Yes	309 (43)	540 (45)	94 (41)
Cold ischemia time (hour)	16 (9-22)	16 (10-21)	16 (10-22)	0.88
KDPI	0.14 (0.07-0.28)	0.15 (0.07-0.28)	0.13 (0.06-0.27)	0.67
Distance	192 (47-341)	177 (41-362)	136 (32-309)	0.24

MELD-XI: Model for end-stage liver disease excluding international normalized ratio; BMI: Body mass index; HCV: Hepatitis C virus; ICU: Intensive care unit; KDPI: Kidney donor profile index; DCD: Donation was after circulatory death.