Preconditioning with sufentanil confers protective effects in transplantation by attenuating hepatic ischemia-reperfusion injury

doi:10.5500/wjt.v16.i2.120865

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World Journal of Transplantation

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2220-3230

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Transplant. Jun 18, 2026; 16(2): 120865
Published online Jun 18, 2026. doi: 10.5500/wjt.v16.i2.120865

Table 4 Molecular mechanisms underlying the protective effects of sufentanil in hepatic ischemia-reperfusion injury

Signaling pathway	Sufentanil effect	Downstream mechanism	Consequences
p38/ERK/JNK/NF-κB-p65/COX-2	Inhibition	Suppression of inflammatory signaling	Cytokines production (decrease)
ATF4/TP53BP2 axis	Downregulation	Reduction of apoptosis	Hepatoprotection
ATF3 pathway	Restoration of ATF3 expression	GPX4 (increase), iron accumulation (decrease)	Attenuation of ferroptosis
HIF-1α/KCNQ1OT1 axis	Reduction of HIF-1α transcriptional activity	KCNQ1OT1 expression (decrease)	Inhibition of ferroptosis
KCNQ1OT1/SRSF1/ACSL4 pathway	ACSL4 levels stabilization	Limitation of PUFA oxidation	Inhibition of ferroptosis

ERK: Extracellular signal-regulated kinase; JNK: C-Jun N-terminal kinase; NF-κB-p65: Nuclear factor kappa-light-chain-enhancer of activated B cells p65 subunit; COX-2: Cyclooxygenase-2; ATF3: Activating transcription factor 3; HIF-1α: Hypoxia-inducible factor 1-alpha; ATF4: Activating transcription factor 4; SRSF1: Serine/arginine splicing factor 1; ACSL4: Acyl-CoA synthetase long-chain family member 4; GPX4: Glutathione peroxidase 4; PUFA: Polyunsaturated fatty acids.

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Citation: Mouratidou C, Pavlidis ET, Katsanos G, Kofinas A, Marneri AG, Stavrati KE, Tsoulfas G, Pavlidis TE. Preconditioning with sufentanil confers protective effects in transplantation by attenuating hepatic ischemia-reperfusion injury. World J Transplant 2026; 16(2): 120865
URL: https://www.wjgnet.com/2220-3230/full/v16/i2/120865.htm
DOI: https://dx.doi.org/10.5500/wjt.v16.i2.120865

Mouratidou C, Pavlidis ET, Katsanos G, Kofinas A, Marneri AG, Stavrati KE, Tsoulfas G, Pavlidis TE. Preconditioning with sufentanil confers protective effects in transplantation by attenuating hepatic ischemia-reperfusion injury. World J Transplant 2026; 16(2): 120865 [PMID: 42281863 DOI: 10.5500/wjt.v16.i2.120865]

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