Preconditioning with sufentanil confers protective effects in transplantation by attenuating hepatic ischemia-reperfusion injury

doi:10.5500/wjt.v16.i2.120865

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World Journal of Transplantation

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2220-3230

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Transplant. Jun 18, 2026; 16(2): 120865
Published online Jun 18, 2026. doi: 10.5500/wjt.v16.i2.120865

Table 1 Key molecular pathways of ferroptosis on hepatic ischemia-reperfusion injury

Regulatory pathway/factor	Mechanism in HIRI
TRPM2	Calcium-calcium overload (increase); ALOX12-dependent lipid peroxidation
IDO-1 (macrophage)	Immune activation
STAT1	miR-497-5p transcription (decrease)-HDAC7 activation
Pro-ferroptotic genes (Hmox1, Tfrc, Slc11a2)	Upregulation
Anti-ferroptotic genes (Slc40a1, Gpx4)	Downregulation
STAT3-HO-1/COX-2 axis	Regulation of iron metabolism and inflammation
JAK2/STAT3 pathway	Release of pro-inflammatory cytokines
MEK/ERK signaling pathway	Regulation of inflammatory response

HIRI: Hepatic ischemia-reperfusion injury; TRPM2: Transient receptor potential melastatin 2; IDO-1: Indoleamine 2, 3-dioxygenase 1; STAT1: Signal transducer and activator of transcription 1; STAT3: Signal transducer and activator of transcription 3; HO-1: Heme oxygenase 1; ALOX12: Arachidonate 12-lipoxygenase; HDAC7: Histone deacetylase 7; COX-2: Cyclooxygenase-2; JAK2: Janus kinase 2; MEK: Mitogen extracellular kinase; ERK: Extracellular signal-regulated kinase.

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Citation: Mouratidou C, Pavlidis ET, Katsanos G, Kofinas A, Marneri AG, Stavrati KE, Tsoulfas G, Pavlidis TE. Preconditioning with sufentanil confers protective effects in transplantation by attenuating hepatic ischemia-reperfusion injury. World J Transplant 2026; 16(2): 120865
URL: https://www.wjgnet.com/2220-3230/full/v16/i2/120865.htm
DOI: https://dx.doi.org/10.5500/wjt.v16.i2.120865

Mouratidou C, Pavlidis ET, Katsanos G, Kofinas A, Marneri AG, Stavrati KE, Tsoulfas G, Pavlidis TE. Preconditioning with sufentanil confers protective effects in transplantation by attenuating hepatic ischemia-reperfusion injury. World J Transplant 2026; 16(2): 120865 [PMID: 42281863 DOI: 10.5500/wjt.v16.i2.120865]

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