Pathogenic analysis of post-transplantation obesity: A comprehensive systematic review

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Mar 18, 2026; 16(1): 112811
Published online Mar 18, 2026. doi: 10.5500/wjt.v16.i1.112811

Table 5 Key adipokine alterations in post-transplantation obesity

Adipokine	Change	Mechanism	Metabolic Consequence	Ref.
Leptin	↑ Secretion	PPARγ inhibition→Leptin resistance	↑Appetite,↑ hepatic glucose output	[25,26]
Adiponectin	↓Secretion (30%–50%)	Impaired PPARγ/AMPK axis	↓Fatty acid oxidation→lipid accumulation	[25,27]
Resistin	↑ Secretion	NF-κB activation by oxidative stress	IRS1 inhibition →↓glucose uptake	[25,29]

Citation: Chen KR, Wu LZ, Huang YN, Zhuang SY, Chen ZY, Xu B, Xu TC. Pathogenic analysis of post-transplantation obesity: A comprehensive systematic review. World J Transplant 2026; 16(1): 112811
URL: https://www.wjgnet.com/2220-3230/full/v16/i1/112811.htm
DOI: https://dx.doi.org/10.5500/wjt.v16.i1.112811

Chen KR, Wu LZ, Huang YN, Zhuang SY, Chen ZY, Xu B, Xu TC. Pathogenic analysis of post-transplantation obesity: A comprehensive systematic review. World J Transplant 2026; 16(1): 112811 [PMID: 41607827 DOI: 10.5500/wjt.v16.i1.112811]

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