Association of vascular invasion and tumor differentiation on post-liver transplant outcomes in patients with hepatocellular carcinoma

Table 1 Recipient characteristics based on vascular invasion, n (%)

Recipient characteristics	None (n = 11672, 85.6%)	Microvascular invasion (n = 1712, 12.6%)	Macrovascular invasion (n = 254, 1.8%)	P value
Age (years), mean (SD)	61.5 (6.8)	61.2 (6.2)	61.6 (6.5)	0.97
Gender, female	2679 (22.9)	322 (18.8)	37 (14.5)	0.10
Model for end-stage liver disease	12.2 (4.9)	12.2 (5.0)	12.2 (4.8)	0.89
AFP
< 100	10,776 (92.2)	1534 (89.6)	220 (86.6)	0.15
100 ≤ AFP < 1000	828 (7.0)	168 (9.8)	31 (12.2)
≥ 1000	68 (0.5)	10 (0.5)	3 (1.1)
Etiology
Hepatitis C virus	7024 (60.1)	1107 (64.6)	152 (59.8)	0.07
Alcohol-associated liver disease	1152 (9.8)	155 (9.0)	17 (6.6)
Metabolic dysfunction-associated steatotic liver disease	1486 (12.7)	195 (11.3)	37 (14.5)
Hepatitis B virus	732 (6.2)	95 (5.5)	13 (5.1)
Other	1278 (10.9)	160 (9.3)	35 (13.7)
Tumor differentiation
Complete necrosis	3125 (26.7)	0 (0)	0 (0)	< 0.001
Well-differentiated	2731 (23.4)	203 (11.8)	27 (10.6)
Moderately-differentiated	5211 (44.6)	1201 (68.4)	170 (61.0)
Poorly-differentiated	605 (5.1)	303 (17.7)	57 (22.4)
Locoregional therapy	7966 (68.2)	1142 (66.7)	183 (72.0)	0.09
Death	2326 (19.9)	572 (33.4)	114 (44.8)	< 0.001

AFP: Alpha fetoprotein.