Critical role of complement in antibody mediated rejection in kidney transplantation

Figure 4 Histopathology of acute antibody-mediated rejection. A: Acute glomerulitis. Some of the glomerular capillary lumens are obliterated by inflammatory cell infiltration and/or endothelial cell swelling (arrow). [hematoxylin and eosin (HE), × 400]; B: Foci of mild peritubular capillaritis with up to 4 inflammatory cells in capillary lumens (ptc1) (arrows) (HE, × 400); C: An interlobar sized artery showing transmural arteritis (v3) (HE, × 400); D: Diffuse C4d positivity (C4d) (C4d3) in peritubular capillaries. Glomerular mesangial positivity serves as the internal control (Flourescein isothiocyanate, immunofluorescence for C4d, × 200).