Donor-recipient age mismatch and outcomes in liver transplantation: A scientific registry of transplant recipients database analysis

Table 3 Multivariate Fine-Gray competing risk regression analysis identifying independent risk factors for different causes of death within 5-year outcomes

Characteristics	All-cause mortality			Graft-related				Infection-related			Cardioneurovascular-related		Malignancy-related			Renal-related
	sHR	95%CI		sHR	95%CI	sHR		95%CI	sHR		95%CI	sHR	95%CI	sHR		95%CI
Donor:recipient age pairs
YAD:YAR	Reference	-	-	Reference	-	-	Reference	-	-	Reference	-	-	Reference	-	-	Reference	-	-
YAD:OAR	1.22	1.17	1.27	0.68	0.60	0.77	1.44	1.27	1.63	1.46	1.32	1.62	1.36	1.22	1.51	1.56	1.07	2.29
MAD:YAR	1.21	1.16	1.26	1.42	1.27	1.59	1.53	1.34	1.74	1.04	0.92	1.17	0.93	0.82	1.05	1.30	0.85	1.99
MAD:OAR	1.34	1.29	1.40	0.87	0.76	0.98	1.91	1.69	2.17	1.45	1.30	1.61	1.31	1.17	1.45	1.90	1.29	2.79
OAD:YAR	1.38	1.24	1.53	1.72	1.32	2.25	2.28	1.71	3.05	0.85	0.59	1.23	0.86	0.63	1.18	1.01	0.32	3.27
OAD:OAR	1.33	1.23	1.44	0.99	0.76	1.28	3.06	2.50	3.74	1.18	0.94	1.49	1.09	0.89	1.33	2.49	1.37	4.53
Recipient diabetes	1.06	1.02	1.09	0.92	0.83	1.02	1.13	1.03	1.24	1.30	1.20	1.41	0.89	0.82	0.96	1.78	1.36	2.32
Recipient diagnosis
ALD	Reference	-	-	Reference	-	-	Reference	-	-	Reference	-	-	Reference	-	-	Reference	-	-
Autoimmune hepatitis	1.13	1.03	1.24	1.12	0.82	1.52	1.32	1.04	1.69	1.29	1.03	1.60	0.72	0.50	1.04	1.19	0.53	2.64
Biliary	0.93	0.87	0.99	1.03	0.84	1.27	1.05	0.88	1.25	0.87	0.74	1.03	1.09	0.90	1.33	0.54	0.26	1.11
HBV	0.96	0.86	1.08	0.93	0.64	1.37	0.73	0.51	1.03	0.86	0.65	1.15	1.96	1.49	2.57	0.64	0.20	2.07
HCC	1.48	1.41	1.56	0.72	0.72	0.72	0.99	0.85	1.16	1.02	0.89	1.17	3.05	2.65	3.50	1.01	0.65	1.57
HCV	1.30	1.25	1.36	2.14	1.87	2.44	1.24	1.10	1.41	1.09	0.97	1.21	1.38	1.21	1.58	1.22	0.84	1.77
Idiopathic	1.06	1.01	1.12	1.03	0.87	1.22	1.01	0.87	1.17	1.26	1.11	1.42	0.88	0.74	1.05	1.13	0.73	1.74
MASH	1.19	1.13	1.26	0.93	0.75	1.14	0.99	0.85	1.16	1.17	1.02	1.33	0.94	0.78	1.14	1.18	0.74	1.85
Other	2.14	1.94	2.36	0.96	0.63	1.45	1.04	0.71	1.52	1.02	0.72	1.44	7.04	5.85	8.47	0.66	0.16	2.77
Recipient functional status
Independent	Reference	-	-	Reference	-	-	Reference	-	-	Reference	-	-	Reference	-	-	Reference	-	-
Mildly dependent	1.25	1.21	1.30	1.09	0.99	1.21	1.34	1.21	1.49	1.30	1.19	1.43	1.08	1.00	1.17	1.10	0.82	1.47
Totally dependent	1.72	1.65	1.80	1.15	1.00	1.32	2.02	1.78	2.30	1.83	1.63	2.04	1.12	0.99	1.26	1.36	0.91	2.05
LDLT (vs DDLT)	1.07	1.00	1.15	0.67	0.51	0.89	1.22	0.98	1.51	0.87	0.71	1.06	0.94	0.79	1.13	0.97	0.48	1.97

Adjusted for donor:recipient age pairs, functional status at transplant, recipient diabetes, transplant indication, living donor liver transplantation vs deceased donor liver transplantation, model for end-stage liver disease/pediatric end-stage liver disease model. CI: Confidence interval; sHR: Subdistribution hazard ratio; YAD: Younger age donors, ≤ 45-years; MAD: Middle-aged donors, 46-69-years; OAD: Older age donors, ≥ 70-years; YAR: Younger age recipients, ≤ 55-years; OAR: Older age recipients, > 55-years; MASH: Metabolic dysfunction-associated steatohepatitis; ALD: Alcohol-related liver disease; HCV: Hepatitis C virus; HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma; LDLT: Living donor liver transplantation; DDLT: Deceased donor liver transplantation.