Donor-recipient age mismatch and outcomes in liver transplantation: A scientific registry of transplant recipients database analysis

Table 2 Multivariable logistic regression analysis for odds of improving functional status at 5 years of post-transplant follow-up

Donor-recipient age pairs	OR	95%CI LL	95%CI UL	P value
YAD:YAR	Reference	-	-	-
YAD:OAR	0.893	0.829	0.963	0.0033
MAD:YAR	0.830	0.767	0.898	< 0.0001
MAD:OAR	0.798	0.734	0.867	< .0001
OAD:YAR	0.527	0.416	0.667	< 0.0001
OAD:OAR	0.674	0.509	0.893	0.006
Recipient diagnosis	-	-	-	-
ALD	Reference	-	-	-
Autoimmune hepatitis	1.045	0.889	1.228	0.595
Biliary	0.774	0.696	0.86	< 0.0001
HBV	1.258	1.056	1.498	0.0102
HCC	0.556	0.486	0.635	< 0.0001
HCV	0.727	0.668	0.791	< 0.0001
Idiopathic	1.443	1.321	1.576	< 0.0001
MASLD/MASH	0.986	0.883	1.102	0.8099
Other	1.032	0.743	1.432	0.852
LDLT (vs DDLT)	0.772	0.644	0.926	0.0051

Adjusted for donor:recipient age pairs, recipient diabetes, indication for transplant, living donor liver transplantation vs deceased donor liver transplantation, model for end-stage liver disease/pediatric end-stage liver disease model. LL: Lower limit; UL: Upper limit; CI: Confidence interval; OR: Odds ratio; YAD: Younger age donors, ≤ 45-years; MAD: Middle-aged donors, 46-69-years; OAD: Older age donors, ≥ 70-years; YAR: Younger age recipients, ≤ 55-years; OAR: Older age recipients, > 55-years; MASH: Metabolic dysfunction-associated steatohepatitis; ALD: Alcohol-related liver disease; DDLT: Deceased donor liver transplantation; HCV: Hepatitis C virus; HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma; MELD: Model for end-stage liver disease; PELD: Pediatric end-stage liver disease model; LDLT: Living donor liver transplantation.