Impact of cytochrome P450 3A5 expression on clinical outcomes in renal transplant recipients receiving tacrolimus-based immunosuppression

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Dec 18, 2025; 15(4): 107636
Published online Dec 18, 2025. doi: 10.5500/wjt.v15.i4.107636

Table 4 Renal parameters of patients with respect to polymorphism

Renal parameter	Expressors (n = 35) (mean ± SD)	Non-expressors (n = 60) (mean ± SD)	P value
Creatinine (mg/dL)
At 1 month	1.8 ± 1.6	1.5 ± 0.4	0.1694
At 3 months	1.9 ± 1.7	1.5 ± 0.4	0.0838
At 6 months	2.0 ± 1.7	1.7 ± 0.6	0.2165
At 9 months	1.9 ± 1.7	1.7 ± 0.5	0.3958
At 12 months	1.7 ± 0.5	1.7 ± 0.4	-
Estimated glomerular filtration rate levels (mL/minute/1.73 m²)
At 1 month	56.4 ± 19.4	62.6 ± 20.7	0.1531
At 3 months	56.2 ± 24.8	59.7 ± 18.2	0.4321
At 6 months	54.2 ± 28.4	54.8 ± 17.5	0.8988
At 9 months	57.9 ± 28.6	53.2 ± 17.4	0.3213
At 12 months	51.0 ± 24.0	53.4 ± 15.7	0.5573

Citation: Pasari AS, Malde S, Tolani P, Ramteke V, Gupta S, Pawar T, Jeyachandran V, Sejpal K, Kurundwadkar M, Gurjar P, Kashiv P, Dubey S, Bawankule C, Kute VB, Deshpande N, Balwani MR. Impact of cytochrome P450 3A5 expression on clinical outcomes in renal transplant recipients receiving tacrolimus-based immunosuppression. World J Transplant 2025; 15(4): 107636
URL: https://www.wjgnet.com/2220-3230/full/v15/i4/107636.htm
DOI: https://dx.doi.org/10.5500/wjt.v15.i4.107636

Pasari AS, Malde S, Tolani P, Ramteke V, Gupta S, Pawar T, Jeyachandran V, Sejpal K, Kurundwadkar M, Gurjar P, Kashiv P, Dubey S, Bawankule C, Kute VB, Deshpande N, Balwani MR. Impact of cytochrome P450 3A5 expression on clinical outcomes in renal transplant recipients receiving tacrolimus-based immunosuppression. World J Transplant 2025; 15(4): 107636 [PMID: 41357367 DOI: 10.5500/wjt.v15.i4.107636]

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