Risk factors for autoimmune liver disease recurrence after liver transplantation

Table 3 Laboratory values before and at three months after liver transplantation, n (%)

Value	Full cohort (n = 79)	Recurrent AILD (n = 21)	Non-recurrent AILD (n = 58)	Odds ratio (95%CI)	P value
Before LT
TB (mg/dL) (mean ± SD)	11.67 ± 12.38	15.49 ± 12.95	10.28 ± 11.99	1.03 (0.99-1.07)	0.108
Direct bilirubin (mg/dL) (mean ± SD)	6.59 ± 7.39	8.70 ± 7.12	5.83 ± 7.40	1.04 (0.98-1.11)	0.137
Indirect bilirubin (mg/dL) (mean ± SD)	5.07 ± 5.34	6.80 ± 6.06	4.45 ± 4.96	1.07 (0.98-1.17)	0.099
ALT (U/L) (mean ± SD)	98.94 ± 132.33	136.94 ± 184.39	85.19 ± 106.34	1.00 (0.99-1.00)	0.147
AST (U/L) (mean ± SD)	144.35 ± 161.63	171.43 ± 177.24	134.54 ± 156.08	1.00 (0.99-1.00)	0.378
AST/ALT (mean ± SD)	1.83 ± 0.72	1.62 ± 0.64	1.91 ± 0.73	0.50 (0.21-1.20)	0.123
Alkaline phosphatase (U/L) (mean ± SD)	285.24 ± 199.90	326.67 ± 254.21	270.24 ± 176.48	1.00 (0.99-1.00)	0.272
Total proteins (g/dL) (mean ± SD)	6.41 ± 1.20	6.35 ± 1.56	6.43 ± 1.05	0.94 (0.61-1.43)	0.782
ALB (g/dL) (mean ± SD)	2.89 ± 0.66	2.70 ± 0.62	2.95 ± 0.67	0.53 (0.24-1.19)	0.128
Globulin (g/dL) (mean ± SD)	3.52 ± 1.36	3.65 ± 1.90	3.47 ± 1.12	1.09 (0.76-1.57)	0.611
ALB/globulin ratio (mean ± SD)	1.01 ± 0.60	1.01 ± 0.66	1.01 ± 0.59	1.01 (0.44-2.31)	0.981
Total leukocyte count (× 103/μL) (mean ± SD)	5.35 ± 3.35	5.47 ± 3.07	5.31 ± 3.47	1.01 (0.87-1.17)	0.848
ALC (× 103/μL) (mean ± SD)	0.82 ± 0.62	0.71 ± 0.46	0.86 ± 0.67	0.64 (0.26-1.59)	0.341
ANC (mean ± SD)	3.88 ± 3.05	4.12 ± 2.79	3.79 ± 3.16	1.03 (0.88-1.21)	0.669
TB > 3 (mg/dL)	61 (77.2)	42 (72.4)	19 (90.5)	3.61 (0.75-17.33)	0.108
ALT > 2 (ULN)	30 (37.9)	18 (31)	12 (57.1)	2.96 (1.06-8.28)	0.038
AST > 2 (ULN)	50 (63.2)	34 (58.6)	16 (76.2)	2.25 (0.72-7.00)	0.158
Three months after LT
TB (mg/dL) (mean ± SD)	1.08 ± 2.56	1.65 ± 4.63	0.84 ± 0.82	1.12 (0.89-1.41)	0.319
ALT (U/L) (mean ± SD)	61.45 ± 179.98	51.47 ± 105.78	65.47 ± 203.19	0.99 (0.99-1.00)	0.765
AST (U/L) (mean ± SD)	41.25 ± 113.26	35.46 ± 67.48	43.59 ± 127.69	0.99 (0.99-1.00)	0.783
ALB (g/dL) (mean ± SD)	4.13 ± 0.50	4.17 ± 0.33	4.11 ± 0.56	1.29 (0.44-3.77)	0.632
Creatinine (mg/dL) (mean ± SD)	0.90 ± 0.25	0.90 ± 0.21	0.90 ± 0.27	1.03 (0.13-7.70)	0.972
Total leukocyte count (× 103/μL) (mean ± SD)	4.47 ± 1.64	4.60 ± 1.42	4.42 ± 1.73	1.06 (0.78-1.45)	0.683
ALC (× 103/mL) (mean ± SD)	1.13 ± 0.73	0.94 ± 0.43	1.21 ± 0.80	0.50 (0.19-1.26)	0.146
ANC (mean ± SD)	2.76 ± 1.18	3.05 ± 1.01	2.65 ± 1.23	1.33 (0.86- 2.07)	0.197

Logistic regression models were used to estimate crude odds ratio and their corresponding 95%CI. ALB: Albumin; ALC: Absolute lymphocyte count; AILD: Autoimmune liver disease; ALT: Alanine aminotransferase; ANC: Absolute neutrophil count; AST: Aspartate aminotransferase; LT: Liver transplantation; TB: Total bilirubin; ULN: Upper limit normal.