Current perspectives and guidelines on liver transplantation for metastatic colorectal cancer

Table 3 Details on the study design, inclusion criteria, transplant type and additional therapy in the studies discussed

Study	Study design	Inclusion criteria	Transplant type	Additional therapy	Key findings
Transmet	Randomized controlled trial	Patients with resected primary tumors, stable disease post-chemotherapy	Deceased donor	Neoadjuvant chemotherapy	Study terminated due to low survival in the transplant group
SECA-III	Randomized controlled trial	Patients with limited liver metastases, controlled with chemotherapy	Deceased donor	Neoadjuvant chemotherapy	Ongoing; results pending
Soulmate	Randomized controlled multicenter	Patients with isolated colorectal liver metastases unsuitable for resection or ablation	Deceased donor (extended criteria)	Neoadjuvant and adjuvant therapy	Ongoing; aims to compare liver transplantation with best established treatment
Excalibur-1	Randomized controlled trial	Patients under 70 with inoperable colorectal liver metastases, insufficient response to current chemotherapy	Deceased donor	Hepatic Arterial infusion (HAI)/FUDR, systemic chemotherapy	Ongoing; compares liver transplantation, HAI/FUDR, and systemic chemotherapy. excaliburstudy.com
Colt	Prospective multicenter	Patients with limited liver metastases, resected primary tumors	Living donor	Neoadjuvant chemotherapy	5-year overall survival: 68%
Melodic	Randomized controlled trial	Patients with metastatic colorectal cancer meeting specific criteria	Deceased donor	Neoadjuvant and adjuvant therapy	Ongoing; results pending
Livermore	Prospective single-center	Patients with limited liver metastases	Deceased donor	Neoadjuvant chemotherapy	Ongoing; results pending
Litoral 2020	Randomized controlled trial	Patients with metastatic colorectal cancer meeting specific criteria	Deceased donor	Neoadjuvant and adjuvant therapy	Ongoing; results pending
NCT04874259	Randomized controlled trial	Patients with metastatic colorectal cancer meeting specific criteria	Deceased donor	Neoadjuvant and Adjuvant Therapy	Ongoing; results pending
Liver(t)wo heal	Prospective multicenter	Patients with limited liver metastases	Living donor	Neoadjuvant chemotherapy	Ongoing; results pending
RAPID-Padova	Prospective single-center	Patients with limited liver metastases	Deceased donor	Neoadjuvant chemotherapy	Ongoing; results pending
Transmetir	Randomized controlled trial	Patients with metastatic colorectal cancer meeting specific criteria	Deceased donor	Neoadjuvant and adjuvant therapy	Ongoing; results pending
NCT02864485	Randomized controlled trial	Patients with metastatic colorectal cancer meeting specific criteria	Deceased donor	Neoadjuvant and adjuvant therapy	Ongoing; results pending
Metliver	Randomized controlled trial	Patients with metastatic colorectal cancer meeting specific criteria	Deceased donor	Neoadjuvant and adjuvant therapy	Ongoing; results pending
NCT06069960	Randomized controlled trial	Patients with metastatic colorectal cancer meeting specific criteria	Deceased donor	Neoadjuvant and adjuvant therapy	Ongoing; results pending
RAPID 2014	Prospective single-center	Patients with limited liver metastases	Deceased donor	Neoadjuvant chemotherapy	Ongoing; results pending